Azilsartan kamedoxomil
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Azilsartan kamedoxomil
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CAS No:
863031-24-7
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Formula:
C30H24N4O8.K
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Chemical Name:
Azilsartan kamedoxomil
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Synonyms:
1H-Benzimidazole-7-carboxylic acid,1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester,potassium salt (1:1);1H-Benzimidazole-7-carboxylic acid,1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester,potassium salt;Azilsartan kamedoxomil;Azilsartan medoxomil monopotassium salt
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CAS No:
Description
Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. IC50 Value: 0.62 nM [2]Target: AT1 receptorin vitro: In aortic endothelial cells, azilsartan inhibited cell proliferation at concentrations as low as 1 μmol/l, whereas valsartan showed little or no antiproliferative effects at concentrations below 10 μmol/l. Antiproliferative effects of azilsartan were a
Azilsartan kamedoxomil is an organic potassium salt that is the monopotassium salt of azilsartan medoxomil. A prodrug for azilsartan, it is used for treatment of hypertension. It has a role as a prodrug, an antihypertensive agent and an angiotensin receptor antagonist. It contains an azilsartan medoxomil(1-).
Safety Information
|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P260, P263, P264, P270, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Azilsartan kamedoxomil Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:606.6
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:10
Exact Mass:606.11529519
Monoisotopic Mass:606.11529519
Topological Polar Surface Area:129
Heavy Atom Count:43
Complexity:1110
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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