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Ferric sulfate

Ferric sulfate structure

CAS No:
10028-22-5
Formula:
Fe.³/2H2O4S
Chemical Name:
Ferric sulfate
Synonyms:
Sulfuric acid,iron(3+) salt (3:2);Iron sulfate (Fe2(SO4)3);Ferric sulfate;Iron persulfate;Iron sesquisulfate;Iron(III) sulfate;Diiron trisulfate;Iron sulfate (2:3);Iron(3+) sulfate;Diiron(3+) sulfate;Amersep 5320;PIX 115;ViscoStat;FS-Pix;PIX 123;PIX 112;Stat Gel;497092-38-3;1299332-62-9
Categories:
Cosmetic Ingredient > Humectant

Description

Yellow crystals or grayish-white powder.(1) slightly soluble in water, (2) very soluble in water. Keep well closed and protected from light. Noncombustible. Ferric Sulfate is a grayish-white powder or yellow lumpy crystals.Ferrous sulfate,also known as ferrisulpas, green copperas, green vitriol, iron sulfate, and melanterite, is composed of blue green monoclinic crystals. It is soluble in water and is used as a mordant for dyeing wool in the textile industry. Ferrous sulfate is also used as

Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with acidic properties. It is produced by the reaction of sulfuric acid and an oxidizing agent. It is used in different fields such as dermatology, dentistry and it is thought to present hemostatic properties by interacting chemically with blood proteins. By the FDA, ferric sulfate is a direct food substance affirmed in the GRAS category (Generally Recognized As Safe).

Ferric sulfate Basic Attributes

Molecular Weight：

399.88

Exact Mass：

399.725

EC Number：

233-072-9

UNII：

3HWS7HF5XD

Characteristics

PSA：

266

XLogP3：

-0.77660

Appearance：

Yellow-gray Powder

Density：

3.097 g/cm³ @ Temp: 18 °C

Melting Point：

480 °C (decomp)

Boiling Point：

101-118 °C @ Press: 760 Torr

Water Solubility：

soluble in water.Sparingly soluble in alcohol.Almost insoluble in acetone and ethyl acetate.Insoluble in sulfuric acid and ammonia.

Storage Conditions：

Store at RT.

Toxicity：

Peritoneal-mouse LD50: 168 mg/kg

Flammability characteristics：

Non-combustible; produces toxic iron and sulfur oxide fumes in the fire

Safety Information

Transport codes：

UN 9121

wgk germany：

hazard class code：

22-36/37

safety instructions：

RTECS Number：

NO8520000

Marks：

Storage features：

Warehouse low temperature, ventilated, dry; moisture-proof; airtight storage

Stability/Shelf Life：

Hydrolyzed slowly in aqueous solution.

Precautionary statement(s)：

P234, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P390, P403+P233, P404, P405, P501

Hazard Statements：

H290

Toxicity

Toxicity class：

moderately toxic

Toxicity Summary：

Ferric sulfate has been proven to be an irritating substance into the eye, throat, gastrointestinal and respiratory tract.

Protein Binding：

Ferric sulfate presents very high protein binding properties, this property is thought to be due to its acidic profile.

Drug Information

Drug Indication：

Ferric sulfate was first used in dermatology as part of the Monsel's solution. This solution is an antihemorrhagic agent used in skin and mucosal biopsies. The use of ferric sulfate in dermatology is under review as ferric sulfate is corrosive and injurious and it can cause degenerative changes that are not observed with other alternatives like collagen. Ferric sulfate is also used as a coagulative and hemostatic agent. It is a mechanic hemostatic agent used directly on the damaged tissue. In dentistry, ferric sulfate is used as a pulpotomy medicament to control pulpal bleeding, as an antibacterial agent and as a hemostatic reagent for restorative dentistry, for postextraction hemorrhage and for periradicular and endodontic surgery.

Pharmacology：

The administration of ferric sulfate as a dermatologic agent has showed delayed reepithelialization and dyspigmentation. Some studies have reported the generation of inflammation in the sites of administration of ferric sulfate.

Absorption：

Pharmacokinetic studies related to the absorption of ferric sulfate have not been performed.|Pharmacokinetic studies related to the elimination of ferric sulfate have not been performed.|Pharmacokinetic studies related to the volume of distribution of ferric sulfate have not been performed.|Pharmacokinetic studies related to the clearance of ferric sulfate have not been performed.

Metabolism/Metabolites：

Pharmacokinetic studies related to the metabolism of ferric sulfate have not been performed.

Biological Half-Life：

Pharmacokinetic studies related to the half-life of ferric sulfate have not been performed.

Mechanism of Action：

The main function of ferric sulfate is as a hemostatic agent in different medical practices. This hemostatic function is achieved when ferric sulfate is applied directly in the damaged tissue. Once applied, ferric sulfate forms ferric ion-protein complex which helps the sealing of the damaged vessels mechanically. The formation of agglutinated protein complexes produces the generation of occlusion in the capillary orifices. The formation of the ferric protein complex is thought to be due to a chemical reaction between the acidic form of ferric sulfate and the blood proteins.

MeSH Entry Terms：

ferric sulfate

Ferric sulfate Use and Manufacturing

In preparation of iron alums, other iron salts and pigments; as coagulant in water purification and sewage treatment; in etching aluminum; in pickling stainless steel and copper; as mordant in textile dyeing and calico printing; in soil conditioners; as polymerization catalyst.

Computed Properties

Molecular Weight:490.0
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:17
Exact Mass:489.777883
Monoisotopic Mass:489.777883
Topological Polar Surface Area:271
Heavy Atom Count:22
Complexity:62.2
Covalently-Bonded Unit Count:10
Compound Is Canonicalized:Yes

Material

Sulfuric acid

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