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Dopamine hydrochloride

Dopamine hydrochloride structure

CAS No:
62-31-7
Formula:
C8H11NO2.ClH
Chemical Name:
Dopamine hydrochloride
Synonyms:
1,2-Benzenediol,4-(2-aminoethyl)-,hydrochloride (1:1);Pyrocatechol,4-(2-aminoethyl)-,hydrochloride;1,2-Benzenediol,4-(2-aminoethyl)-,hydrochloride;Dopamine hydrochloride;3-Hydroxytyramine hydrochloride;β-(3,4-Dihydroxyphenyl)ethylamine hydrochloride;3,4-Dihydroxyphenethylamine hydrochloride;Intropin;Dopamine chloride;m-Hydroxytyramine hydrochloride;P 498;2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride;KW 3160;Inovan;Revivan;3,4-Dihydroxy-β-phenethylamine hydrochloride;Tensamin;Rascordin;Dynatra;Cardiosteril;Inotropin;Dopastat;ASL 279;Dopamine Fresenius;Dopamine Pierre Faba;4-(2-Aminoethyl)-1,2-benzenediol hydrochloride;Dopadic;Dopmin;2-(3,4-Dihydroxyphenyl)ethanaminium chloride;H 8502;1477-71-0;2002410-63-9
Categories:
Organic Chemistry > Amides

Description

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.Target: Dopamine ReceptorDopamine (or 3,4-dihydroxyphenethylamine) is a neuroendocrine transmitter in the catecholamine and phenethylamine families that plays a number of important roles in the brain and bodies of humans. Several important diseases of the nervous system are associated with dysfunctions of the dopamine system. Outside the nervous system, dopamine fun

Dopamine hydrochloride is a catecholamine.|Dopamine Hydrochloride is the hydrochloride salt form of dopamine, a monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- and beta-1- adrenergic receptors. Mediated through myocardial beta-1-adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1-adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output.|One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Dopamine hydrochloride Basic Attributes

Molecular Weight：

189.64

Exact Mass：

189.055649

BRN：

3656720

EC Number：

200-527-8

UNII：

7L3E358N9L

NSC Number：

756749|169105

DSSTox ID：

DTXSID7020550

NCI Thesaurus Code：

C455

HScode：

29222900

Characteristics

PSA：

66.5

XLogP3：

2.10130

Appearance：

light tan Crystalline Powder

Density：

1.4 g/cm3

Melting Point：

220 °C (decomp) @ Solvent: Water

Boiling Point：

337.7ºC at 760 mmHg

Flash Point：

11℃

Water Solubility：

alcohol: 20 mg/mL

Storage Conditions：

Store at -20°C

Toxicity：

Oral-Rat LD50 2859 mg/kg; Oral-Mouse LD50: 4361 mg/kg

Flammability characteristics：

Flammable, decomposes toxic nitrogen oxides and chloride gases when burned

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

36/37/38-50/53-22-39/23/24/25-23/24/25-11

safety instructions：

26-36-61-45-36/37-16

RTECS Number：

UX1092000

Marks：

Xi,N,Xn,T,F

Storage features：

Warehouse low temperature, ventilated, dry

Hazard note：

Irritant

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents. Combustible.

Precautionary statement(s)：

P273-P501

Hazard Statements：

H302-H410

GHS Classification：

|Warning|H302 (96.6%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 206 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)|Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

MeSH Entry Terms：

3,4 Dihydroxyphenethylamine

Dopamine hydrochloride Use and Manufacturing

Methods of Manufacturing

Derived from the opening of piperidine. Piperonylamine and phenol were added to the reaction pot, cooled, hydrochloric acid was slowly added, and the temperature was raised to 110°C and refluxed for 12-44h. After the reaction reaches the end, it is a little cold, and it is stirred evenly by adding water. Set aside for separation and remove the phenol layer. The water layer was extracted with isopropyl acetate, and the water layer after extraction was evaporated to dryness under reduced pressure (8.0 kPa), then 1/2 amount of ethanol and hydrochloric acid were added, and dissolved by heating. Cool, crystallize, filter, wash the filter cake with ethanol, and dry to get the finished product. The yield was 74%.

Uses

dopaminergic

Manufacturing Info：

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (1:1): ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:189.64
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:189.0556563
Monoisotopic Mass:189.0556563
Topological Polar Surface Area:66.5
Heavy Atom Count:12
Complexity:119
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S. P. A.

Japan
Active
桂化学株式会社

Japan
Active
Siegfried PharmaChemikalien Minden GmbH

Germany
Active

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