Acid Orange 10

452.37

451.972473

217-705-6

1Q6EJU80RN

DTXSID6021082

YELLOWISH-RED CRYSTALS OR LEAFLETS

32041200

176.11000

4.93060

Red to Orange Powder

0.80 g/mL at 20 °C

141 °C

14 °C

H2O: 5 g/100 mL (20 ºC)

2-8°C

LD50 orally in Rabbit: > 3000 mg/kg

pKa = approx. 11.5 at room temperature in water

Azo dyes can be explosive when suspended in air at specific concentrations. This organic acid has a moderate soluble in water. The resulting solutions contain concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid.

Azo, Diazo, Azido, Hydrazine, and Azide Compounds

Explosive

C.I. ACID ORANGE 10 is an azo compound. Toxic gases are formed by mixing compounds containing azo groups with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. This compound becomes redder and more dull when mixed with copper. It is almost destroyed when mixed with iron. (NTP, 1992)

UN19873/PG2

3

36/37/38-11

22-24/25-37/39-26-16-7-36/37

QJ6500000

Xi,F

Stable. Incompatible with strong oxidizing agents.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

DHHS/NTP; Toxicology & Carcinogenesis Studies of C.I Acid Orange 10 in F344/N Rats and B6C3F1 Mice (Feed Studies) Technical Report Series No. 211 (1987) NIH Publication No. 88-1767

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Not Classified

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient conditions. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Carcinogenesis studies of 80% pure C.I. Acid Orange 10 (a monoazo textile dye) were conducted by feeding to-groups of 50 male and 50 female F344/N rats diets containing 1,000 or 3,000 ppm C.I. Acid Orange 10 for 103 weeks. Groups of 50 male and 50 female B6C3Fl mice were fed diets containing 3,000 or 6,000 ppm for 103 weeks. Groups of 90 male and 90 female untreated rats and 50 male and 50 female untreated mice served as controls. ... Under these conditions, there was no evidence of carcinogenicity for male and female F344/N rats or for male and female B6C3Fl mice. ... Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative

Orange G's production and use in the staining of paper and wood, the dyeing of textiles and leather, its use in inks and colored pencils and as a biological stain(1), and former use in cosmetics(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 0(SRC), determined from an estimated log Kow(2,SRC) and a recommended regression-derived equation(3), indicates that Orange G will have very high mobility in soil(SRC); however, its ionic nature may result in ion-exchange processes with clay that would retard leaching(8). Orange G is expected to be resistant to aerobic biodegradation(4); it may be biodegraded anaerobically as a wide variety of anaerobic bacteria have the ability to cleave the azo linkage to produce aromatic amines(5). Since Orange G is an ionic compound, volatilization from moist soil surfaces will not be important(8). Volatilization of Orange G is not expected to be important from dry soil surfaces(SRC) based on its estimated vapor pressure(6,SRC). Orange G is not expected to be susceptible to direct photolysis on soil surfaces based on its absorption of light at wavelengths >290 nm(SRC) (absorption max = 474 nm)(7).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 0(SRC), determined from an estimated log Kow(2,SRC) and a recommended regression-derived equation(1), indicates that Orange G is not expected to adsorb to suspended solids and sediment in the water(SRC). However, its ionic nature may result in ion-exchange porcesses with clay particles resulting in increased adsorption to sediment and particulate material(6). Orange G is expected to be resistant to aerobic biodegradation(3); it may biodegrade anaerobically as a wide variety of anaerobic bacteria have the ability to cleave the azo linkage to produce aromatic amines(4). In a humic acid solution, Orange G showed enhanced photodegradation as compared to a distilled water solution, indicating that Orange G is photosensitized in the presence of humics(5). Since Orange G is an ionic compound, volatilization from moist soil surfaces will not be important(6). An estimated BCF value of 0(1,SRC), from an estimated log Kow(2,SRC), suggests that Orange G will not bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), Orange G, which has an estimated vapor pressure of 2.5X10-20 mm Hg at 25 °C(2), exists solely in the particulate phase in the ambient atmosphere. Particulate-phase Orange G may be physically removed from the air by wet and dry deposition(SRC).

Orange G did not precipitate in water with a calcium concentration of 10-3 M(1). Orange G, added to distilled water and subjected to photolysis, had half-lives of 340 and 32 hours for the protonated and dissociated forms, respectively(2). These half-lives decreased to 44 and 1.8 hours for the protonated and dissociated forms, respectively, when Orange G was added to a humic solution (5 mg/l total organic carbon) and the solution was subjected to photolysis(2). These results suggest that photodegradation of Orange G is photosensitized in the presence of humics, although concentrations of photochemical oxidant produced during this experiment were considerably greater than those normally seen in the natural environment(2).

An estimated BCF value of 0 was calculated for Orange G(SRC), using an estimated log Kow of -4.56(1,SRC) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration of Orange G in aquatic organisms will not be an important fate process(SRC).

The Koc of Orange G is estimated as approximately 0(SRC), using an estimated log Kow of -4.56(1,SRC) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that Orange G has very high mobility in soil(SRC). The ionic nature of Orange G may result in ion-exchange processes with clay that would retard leaching(4).

Since Orange G is an ionic compound, volatilization from moist soil surfaces will not be important(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 27,557 workers (12,180 of these are female) are potentially exposed to Orange G in the USA(1).

OF 500 MG/KG BODY WT ORANGE G FED TO RABBITS, 40% IS EXCRETED IN THE URINE AS PARA-AMINOPHENOL, 3% AS ORTHO-AMINOPHENOL AND 0.6% AS FREE ANILINE... IN THE URINE OF RATS GIVEN SINGLE ORAL DOSES OF 250 MG/KG BODY WT, 61% APPEARS AS PARA-AMINOPHENOL, AND ANILINE IS FOUND IN FECES. NO UNCHANGED DYE IS FOUND IN EITHER THE URINE OR THE FECES...|THE URINE OF HUMANS GIVEN 20 MG/KG BODY WEIGHT ORANGE G CONTAINED 95% AS PARA-AMINOPHENOL, 0.5% AS ANILINE AND 1.3% AS UNCHANGED COLOR...|THE AZO LINKAGE OF ORANGE G IS REDUCED BY BACTERIA PRESENT IN RAT FECES AND BY RAT-LIVER HOMOGENATES...

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of carbon oxides, nitrogen oxides, sulfur oxides and disodium oxide. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

1-phenylazo-2-naphthol-6,8-disulfonic acid, disodium salt

SPECIFICATIONS FOR ORANGE G ARE GIVEN BY THE BRITISH STANDARDS INSTITUTION (1960), TOGETHER WITH APPROPRIATE ANALYTICAL METHODS: THE PRODUCTS MUST CONTAIN A MINIMUM OF 85% OF THE COLOR...

1,3-Naphthalenedisulfonic acid, 7-hydroxy-8-(2-phenyldiazenyl)-, sodium salt (1:2): ACTIVE

IDENTIFICATION OF WATER-SOLUBLE COLORS IN FOOD USING THIN-LAYER CHROMATOGRAPHY.

Cosmetics -> Cosmetic colorant

Food Additives -> COLOUR;