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Buflomedil hydrochloride

Buflomedil hydrochloride structure

CAS No:
35543-24-9
Formula:
C17H25NO4.ClH
Chemical Name:
Buflomedil hydrochloride
Synonyms:
1-Butanone,4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-,hydrochloride (1:1);1-Butanone,4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-,hydrochloride;LL 1656;Buflomedil hydrochloride;Irrodan R;Fonzylane;Buflocit;Lofton;Buflan;Provas;Loftyl;Bufedil;Irrodan;Buflonat;1-[3-(2,4,6-Trimethoxybenzoyl)Propyl]PyrrolidiniumChloride
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease.Target: OthersBuflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease. In the EU, buflomedil, a vasoactive agent, was indicated for treatment of PAOD symptoms, specifically in patients with stage II PAOD who experience severe pain when walking even relatively short distances. Buflomedil is not currently approved by the US Food and Dru

Buflomedil hydrochloride Basic Attributes

Molecular Weight：

343.85

Exact Mass：

343.155029

EC Number：

252-611-9

HScode：

2933990090

Characteristics

PSA：

XLogP3：

3.51100

Appearance：

White or off-white crystalline powder

Melting Point：

192-193 °C

Boiling Point：

454.5°C at 760 mmHg

Flash Point：

228.7ºC

Toxicity：

Oral-rat LD50: 410 mg/kg; Oral-Mouse LD50: 275 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides and hydrogen chloride fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

EL9885000

Storage features：

The warehouse is ventilated, low temperature and dry; stored separately from food raw materials

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Toxicity

Toxicity class：

highly toxic

Buflomedil hydrochloride Use and Manufacturing

Methods of Manufacturing

In a separate dry reaction flask, 33.6 g of 1, 3, 5-trimethoxybenzene and 27.2 g of anhydrous zinc chloride were added.Dichloromethane 300mL, stirring and cooling to 0-5 degrees after dropping 36.5g 1-pyrrolidinoyl chloride, drops, The reaction was heated to reflux for 2 hours. After the reaction was complete, 15 mL of concentrated hydrochloric acid and 150 mL of pure water were added and washed.The resulting organic phase is washed with saturated sodium bicarbonate solution to a pH of 7-8, and the organic phase is dried over magnesium sulfate and then reduced to dryness.Add 100 mL of anhydrous ethanol to the concentrate.20percent hydrochloric acid ethanol100mLAfter stirring the reaction at 60-70°C for 1 hour, the ethanol is then reduced to dryness.After adding 400 mL of acetone to the residue and cooling and crystallizing, the white crystal was filtered to obtain 60.2 g of buflomedil hydrochloride.

Uses

Buflomedil is used as an vasodilator (peripheral).

Drug Function and Efficacy

It is an α-adrenergic receptor inhibitor and has a weak nonspecific calcium ion antagonist effect. It improves the microcirculation blood flow in the brain and limbs by inhibiting the spasm of the precapillary sphincter. It also has the function of inhibiting platelet aggregation and improving red blood cell deformability.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Buflomedil Hydrochloride Tablets
Ingredients	The main ingredient of this product is buflomedil hydrochloride. Its chemical name is 4-(1-pyrrolidinyl)-1-(2,4,6-trioxyphenyl) 4-butanone hydrochloride.
Indication	Use with caution in patients taking antihypertensive drugs.
Specifications	0.15g*12s

Buflomedil Hydrochloride Tablets
Ingredients	The main ingredient of this product is buflomedil hydrochloride. Its chemical name is 4-(1-pyrrolidinyl)-1-(2,4,6-trioxyphenyl) 4-butanone hydrochloride.
Indication	Use with caution in patients taking antihypertensive drugs.
Specifications	0.15 g

Buflomedil hydrochloride sustained-release tablets
Ingredients	Main ingredients: The main ingredient of this product is buflomedil hydrochloride. Its chemical name is 4-(1-pyrrolidinyl)-1-(2,4,6-trioxyphenyl) 4-butanone hydrochloride. Molecular formula: C17H25NO4HCl Molecular weight: 343.85 In addition to the active ingredient, this drug also contains the following excipients: lactose 60mg; corn starch 36.7mg; povidone 5.6mg; microcrystalline cellulose 53.3mg; glycerol palmitic acid 20mg; talc 8.4mg; magnesium stearate 2.
Indication	When used in combination with antihypertensive drugs, it may aggravate the drop in blood pressure and should be used with caution.
Specifications	0.6 g

See More Related Drugs

Registered Holders

ISOCHEM

France
Active
ISOCHEM Vert Le

European Union
Active
AMDIPHARM LIMITED

European Union
Inactive

See More Registered Holders

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CAS No.: 35543-24-9

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99% High Value Purity Chemicals Buflomedil Hydrochloride 35543-24-9

CAS No.: 35543-24-9

Grade: Pharmaceutical Grade

Content: 0.00%

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