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Cefetamet pivoxil hydrochloride

Cefetamet pivoxil hydrochloride structure

CAS No:
111696-23-2
Formula:
C20H25N5O7S2.ClH
Chemical Name:
Cefetamet pivoxil hydrochloride
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-methyl-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester,hydrochloride (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester,monohydrochloride,[6R-[6α,7β(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester,monohydrochloride,(6R,7R)-;Ro 15-8075;Cefetamet pivoxil hydrochloride;Cefetamet (pivaloyloxy)methyl ester hydrochloride;Cefyl;105629-49-0;220487-29-6
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefetamet pivoxil hydrochloride, an ester prodrug of cefetamet, is an orally active cephalosporin introduced for the treatment of community-acquired respiratory and urinary tract infections. Roche indicated that this drug will possibly be the first third-generation cephalosporin to be launched in some counrries. It is reportedly useful in penicillin-resistant pneumococci, gonococci and H. influenzae infections, but ineffective against Staphylococci, P. aeruginosa and some non-fermenters.

Cefetamet pivoxil hydrochloride Basic Attributes

Molecular Weight：

548.03

Exact Mass：

547.096191

DSSTox ID：

DTXSID1048590

HScode：

2941905990

Characteristics

PSA：

216

XLogP3：

2.55170

Boiling Point：

732.3°C at 760 mmHg

Flash Point：

396.7ºC

Vapor Pressure：

9.78E-22mmHg at 25°C

Cefetamet pivoxil hydrochloride Use and Manufacturing

This product is the third generation of oral broad-spectrum cephalosporin antibiotics.

Computed Properties

Molecular Weight:548.0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:547.0962182
Monoisotopic Mass:547.0962182
Topological Polar Surface Area:216
Heavy Atom Count:35
Complexity:933
Defined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an oral third-generation broad-spectrum cephalosporin antibiotic. It has strong antibacterial activity against Gram-positive bacteria such as Streptococcus (except faecal Streptococcus) and Streptococcus pneumoniae; Gram-negative bacteria such as Escherichia coli, Haemophilus influenzae, Klebsiella, Salmonella, Shigella, and Neisseria gonorrhoeae, especially against Serratia, indole-positive Proteus, Enterobacter, and Citrobacter, which are less sensitive to cephalosporins. It is stable to β-lactamase produced by bacteria. However, this product is ineffective against drug-resistant microorganisms such as Pseudomonas, Mycoplasma, Chlamydia, and Enterococcus.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefetamet Pivoxil Hydrochloride Dispersible Tablets
Ingredients	The main ingredient of this product is cefetamet pivoxil hydrochloride, and its chemical name is (6R,7R)-3-methyl-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-acetylamino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid pivaloyloxymethyl ester hydrochloride.
Indication	Antacids and H2 receptor antagonists have no effect on the pharmacokinetics of this product. So far, there have been no reports of this product affecting laboratory test values and/or methods, and no damage to renal function has been observed in patients receiving concomitant diuretic therapy when using this product.
Specifications	0.25g
Manufacturer	Hainan Quanxing Pharmaceutical Co., Ltd.

Cefetamet Pivoxil Hydrochloride
Manufacturer	Sichuan Ren An Pharmaceutical Co., Ltd.

Cefetamet Pivoxil Hydrochloride Tablets
Ingredients	The main ingredient of this product is cefetamet pivoxil hydrochloride
Indication	Antacids and H3 receptor antagonists have no effect on the pharmacokinetics of this product. So far, there have been no reports of this product affecting laboratory test values and/or methods, and no damage to renal function has been observed in patients receiving concomitant diuretic therapy when using this product.
Specifications	181.3mg (calculated as C14H15N5O5S2)
Manufacturer	Zhejiang Yongning Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active
Zhejiang Yongning Pharmaceutical Co., Ltd.

China
Active
Zhejiang Apeloa Tospo Pharmaceutical Co., Ltd.

China
Active

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Guide of Cefetamet pivoxil hydrochloride

Description
Basic Attributes
Characteristics
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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