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Hydroxycamptothecin

Hydroxycamptothecin structure

CAS No:
19685-09-7
Formula:
C20H16N2O5
Chemical Name:
Hydroxycamptothecin
Synonyms:
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-,(4S)-;Camptothecine,10-hydroxy-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-,(S)-;(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;10-Hydroxycamptothecine;Hydroxycamptothecin;10-Hydroxycamptothecin;(S)-10-Hydroxycamptothecin;NSC 107124;(+)-10-Hydroxycamptothecin;ChEMBL 273862;10-HCPT;104155-90-0;157405-42-0
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

(S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [

10-Hydroxycamptothecin is a pyranoindolizinoquinoline.|10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)).

Hydroxycamptothecin Basic Attributes

Molecular Weight：

364.35

Exact Mass：

364.35

EC Number：

2017-001-1

UNII：

9Z01632KRV

NSC Number：

107124

HScode：

2934999090

Characteristics

PSA：

100

XLogP3：

1.32

Density：

1.6±0.1 g/cm3

Melting Point：

268-270 °C @ Solvent: Chloroform, Methanol, Ethyl acetate

Boiling Point：

820.7°C at 760 mmHg

Flash Point：

450.1±34.3 °C

Refractive Index：

1.777

Storage Conditions：

-20°C Freezer

Collision Cross Section：

187 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

safety instructions：

24/25

Precautionary statement(s)：

P201, P202, P260, P264, P270, P273, P281, P308+P313, P314, P405, P501

Hazard Statements：

H340

GHS Classification：

|Danger|H301+H311+H331 (50%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

MeSH Entry Terms：

10-hydroxycamptothecin

Hydroxycamptothecin Use and Manufacturing

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

Computed Properties

Molecular Weight:364.4
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:364.10592162
Monoisotopic Mass:364.10592162
Topological Polar Surface Area:100
Heavy Atom Count:27
Complexity:774
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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