N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine
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N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine
structure -
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CAS No:
71989-33-8
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Formula:
C22H25NO5
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Chemical Name:
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine
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Synonyms:
L-Serine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine;N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine;O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)serine;(2S)-3-tert-Butoxy-2-[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]propanoic acid;Fmoc-Ser(OtBu)-OH;Fmoc-L-Ser(tBu)-OH;(2S)-3-(tert-Butoxy)-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)propanoic acid;(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid;487011-58-5;1454836-22-6;2041577-21-1
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CAS No:
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine Basic Attributes
383.44
383.44
276-260-6
2924299090
Characteristics
84.9
3.5
White to off-white powder
1.2±0.1 g/cm3
128-131 °C
578.6ºC at 760 mmHg
303.7±30.1 °C
1.575
2-8°C
25 º (c=1,EtOAc 24 ºC)
Safety Information
NONH for all modes of transport
3
36/37/38
24/25-36/37/39-27-26
Xi
Stable under normal temperatures and pressures.
P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P321, P322, P330, P333+P313, P363, P501
H302
|Warning|H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P321, P322, P330, P333+P313, P363, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine Use and Manufacturing
Suspend O-tert-butyl-L-serine in dioxane solution and acylate with fluorenylmethyloxycarbonyl azide to obtain a crude product, which is extracted with ethyl acetate at a pH of 9-10. Refined by recrystallization.
Used for peptide synthesis and as amino acid protection monomer.
Computed Properties
Molecular Weight:383.4
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:383.17327290
Monoisotopic Mass:383.17327290
Topological Polar Surface Area:84.9
Heavy Atom Count:28
Complexity:536
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine
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