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Amprolium hydrochloride

Amprolium hydrochloride structure

CAS No:
137-88-2
Formula:
C14H19N4.ClH.Cl
Chemical Name:
Amprolium hydrochloride
Synonyms:
Pyridinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-,chloride,hydrochloride (1:1:1);2-Picolinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-,chloride,monohydrochloride;Pyridinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-,chloride,monohydrochloride;1-(4-Amino-2-propyl-5-pyrimidinylmethyl)-2-methylpyridinium chloride hydrochloride;1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-picolinium chloride hydrochloride;Amprol;Mepyrium;Amprol 25;Amprolium hydrochloride;Thiacoccid;Amdon;8017-99-0;8027-83-6
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Amprolium hydrochloride is a coccidiostat used in poultry, is a thiamine analogue and blocks the thiamine transporter of Eimeria species by blocking thiamine uptake it prevents carbohydrate synthesis.

A veterinary coccidiostat that interferes with THIAMINE metabolism.

Amprolium hydrochloride Basic Attributes

Molecular Weight：

315.24

Exact Mass：

314.106506

EC Number：

205-307-5

UNII：

95CO6N199Q

NSC Number：

755872|523454

DSSTox ID：

DTXSID0045547

HScode：

29335995

Characteristics

PSA：

55.7

XLogP3：

0.04270

Appearance：

White to Off-white Powder

Melting Point：

246-247 °C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

22-24/25-36-26

RTECS Number：

TJ7565000

Marks：

Drug Information

MeSH：

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

MeSH Entry Terms：

Amprol

Amprolium hydrochloride Use and Manufacturing

Methods of Manufacturing

Taking the intermediate for the production of vitamin B1 as the raw material, it is cyclized, hydrolyzed and ring-opened, then diazotized to convert the amino group into a hydroxyl group, and finally obtained by condensation.

Uses

Thiamine analog coccidiostat.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:315.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:314.1065020
Monoisotopic Mass:314.1065020
Topological Polar Surface Area:55.7
Heavy Atom Count:20
Complexity:246
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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