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Bismuth subcitrate

Bismuth subcitrate structure

CAS No:
57644-54-9
Formula:
C6H8O7.¹/2Bi.³/2K
Chemical Name:
Bismuth subcitrate
Synonyms:
1,2,3-Propanetricarboxylic acid,2-hydroxy-,bismuth(3+) potassium salt (2:1:3);Tripotassium dicitratobismuthate;Duosol;Duosol (ulcer treatment);De-Nol;Bismuth subcitrate;De-Noltab;Gastrodenol;Ulcerone;CBS;Colloidal bismuth subcitrate;Q-Ulcer;Bicit HP;Trymo;Bismuth tripotassium dicitrate
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Bismuth Subcitrate is a mineral compound that is used to treat duodenal and gastric ulcers associated with Helicobacter pylori.

Bismuth subcitrate Basic Attributes

Molecular Weight：

704.47

Exact Mass：

703.879

EC Number：

260-872-5

UNII：

HS813P8QPX

NCI Thesaurus Code：

C1351

ATC Code：

A - Alimentary tract and metabolism

Characteristics

PSA：

281

XLogP3：

-6.73240

Boiling Point：

309.6°C at 760 mmHg

Flash Point：

155.2ºC

Safety Information

Hazard category：

IRRITANT

RTECS Number：

TZ8492900

Drug Information

Drug Indication：

Helicobacter pylori infection

MeSH：

Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT. (See all compounds classified as Antacids.)|Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)|Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

MeSH Entry Terms：

Bi-citrate

Bismuth subcitrate Use and Manufacturing

Uses

Stomach medicine can promote the regeneration of epithelial cells and thoroughly kill Helicobacter pylori

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:704.47
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:4
Exact Mass:703.87857
Monoisotopic Mass:703.87857
Topological Polar Surface Area:281
Heavy Atom Count:30
Complexity:211
Covalently-Bonded Unit Count:6
Compound Is Canonicalized:Yes

Drug Function and Efficacy

In the acidic environment of the stomach, a diffuse protective layer is formed to cover the ulcer surface, preventing gastric acid, enzymes and food from invading the ulcer; it reduces the activity of pepsin, increases mucin secretion, and promotes the release of prostaglandins from the mucosa, thereby protecting the gastric mucosa; it has a killing effect on Helicobacter pylori (HP), thereby promoting the healing of gastritis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Bismuth Potassium Citrate Granules
Ingredients	Each bag of this product contains 0.3g of potassium citrate bismuth (equivalent to 0.11g of bismuth). Excipients: mannitol, sodium carboxymethyl cellulose
Indication	1. Milk and antacids can interfere with the effect of this product and should not be taken at the same time. 2. Taking it with tetracycline will affect the latter's absorption. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	1.0g: 110mg bismuth
Manufacturer	North China Pharmaceutical Company.Ltd

Bismuth Potassium Citrate Granules
Ingredients	The main ingredient of this product is potassium bismuth citrate, which is a bismuth-containing complex with uncertain composition.
Indication	1. Milk and antacids can interfere with the effect of this product and should not be taken at the same time. 2. Taking it with tetracycline will affect the latter's absorption. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Each bag 1.0g: 110mg bismuth
Manufacturer	Jilin Aodong Yanbian Pharmaceutical Co., Ltd.

Bismuth Potassium Citrate Granules
Ingredients	Each bag of this product contains 0.3g of potassium citrate bismuth (equivalent to 0.11g of bismuth). Excipients: mannitol, sodium carboxymethyl cellulose
Indication	1. Milk and antacids can interfere with the effect of this product and should not be taken at the same time. 2. Taking it with tetracycline will affect the latter's absorption. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Each bag 1.0g: contains bismuth 110mg
Manufacturer	Sinopharm Ronshyn Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Ruisheng Pharmaceutical (Henan) Co., Ltd.

China
Active
5N Plus Lübeck GmbH

Belgium
Active
Shanghai Modern Hasen (Shangqiu) Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Bismuth subcitrate

Shandong Airuike Chemical Co., Ltd. Contact Supplier

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Potassium bismuth citrate CAS 57644-54-9

CAS No.: 57644-54-9

Grade: Pharmaceutical Grade

Content: 99%

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LUYUNJIA CHEMISTRY XIAMEN LIMITED Contact Supplier

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5 YRS

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Bismuth Potassium Citrat 57644-54-9

CAS No.: 57644-54-9

Content: 99%

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