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Selamectin

Selamectin structure

Selamectin 

structure
  • CAS No:

    220119-17-5

  • Formula:

    C43H63NO11

  • Chemical Name:

    Selamectin

  • Synonyms:

    Avermectin A1a,25-cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-;(5Z)-25-Cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a;Selamectin;Revolution;Revolution (antibiotic);Stronghold;Evicto;Chanhold;Selarid

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Selamectin Basic Attributes

769.967

769.96

1592732-453-0

DTXSID6045903

QP54AA05|QP54AA55

2932206000

Characteristics

155

1.35±0.1 g/cm3(Predicted)

917°C at 760 mmHg

2-8°C

293.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

3

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P273, P281, P308+P313, P391, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]|P260, P273, P314, P391, and P501

Drug Information

, Treatment and prevention of flea infestations caused by Ctenocephalides spp. for one month following a single administration. This is as a result of the adulticidal, larvicidal and ovicidal properties of the product. The product is ovicidal for 3 weeks after administration. Through a reduction in the flea population, monthly treatment of pregnant and lactating animals will also aid in the prevention of flea infestations in the litter up to seven week of age. The product can be used as part of a treatment strategy for flea allergy dermatitis and through its ovicidal and larvicidal action may aid in the control of existing environmental flea infestations in area to which the animal has access., Prevention of heartworm disease caused by Dirofilaria immitis with monthly administration. The product may be safely administered to animals infected with adult heartworms, however, it is recommended, in accordance with good veterinary practice, that all animals 6 months of age or more living in countries where a vector exists should be tested for existing adult heartworm infections before beginning medication with the product. It is also recommended that dogs should be tested periodically for adult heartworm infections, as an integral part of a heartworm prevention strategy, even when the product has been administered monthly. This product is not effective against adult D. immitis., Treatment of ear mites (Otodectes cynotis)., , , Cats:, , , Treatment of biting lice infestations (Felicola subrostratus), Treatment of adult roundworms (Toxocara cati), Treatment of adult intestinal hookworms (Ancylostoma tubaeforme)., , , Dogs:, , , Treatment of biting lice infestations (Trichodectes canis), Treatment of sarcoptic mange (caused by Sarcoptes scabiei), Treatment of adult intestinal roundworms (Toxocara canis)., ,|Cats and dogs:, , Treatment and prevention of flea infestations caused by Ctenocephalides spp. for one month following a single administration. This is as a result of the adulticidal, larvicidal and ovicidal properties of the product. The product is ovicidal for 3 weeks after administration. Through a reduction in the flea population, monthly treatment of pregnant and lactating animals will also aid in the prevention of flea infestations in the litter up to seven weeks of age. The product can be used as part of a treatment strategy for flea allergy dermatitis and through its ovicidal and larvicidal action may aid in the control of existing environmental flea infestations in areas to which the animal has access., , Prevention of heartworm disease caused by Dirofilaria immitis with monthly administration., , The product may be safely administered to animals infected with adult heartworms, however, it is recommended, in accordance with good veterinary practice, that all animals 6 months of age or more living in countries where a vector exists should be tested for existing adult heartworm infections before beginning medication with the product. It is also recommended that dogs should be tested periodically for adult heartworm infections, as an integral part of a heartworm prevention strategy, even when the product has been administered monthly. This product is not effective against adult D. immitis., , Treatment of ear mites (Otodectes cynotis)., , Cats:, , , Treatment of biting lice infestations (Felicola subrostratus), Treatment of adult roundworms (Toxocara cati), Treatment of adult intestinal hookworms (Ancylostoma tubaeforme), Treatment of biting lice infestations (Trichodectes canis), Treatment of sarcoptic mange (caused by Sarcoptes scabiei), ,|For cats with, or at risk from, mixed parasitic infestations by ticks and fleas, lice, mites, gastrointestinal nematodes or heartworm. The veterinary medicinal product is exclusively indicated when use against ticks and one or more of the other target parasites is indicated at the same time.|Cats and dogs: Treatment and prevention of flea infestations caused by Ctenocephalides spp. for one month following a single administration. This is as a result of the adulticidal, larvicidal and ovicidal properties of the product. The product is ovicidal for 3 weeks after administration. Through a reduction in the flea population, monthly treatment of pregnant and lactating animals will also aid in the prevention of flea infestations in the litter up to seven weeks of age. The product can be used as part of a treatment strategy for flea allergy dermatitis and through its ovicidal and larvicidal action may aid in the control of existing environmental flea infestations in areas to which the animal has access.Prevention of heartworm disease caused by Dirofilaria immitis with monthly administration. Stronghold may be safely administered to animals infected with adult heartworms, however, it is recommended, in accordance with good veterinary practice, that all animals 6 months of age or more living in countries where a vector exists should be tested for existing adult heartworm infections before beginning medication with Stronghold. It is also recommended that dogs should be tested periodically for adult heartworm infections, as an integral part of a heartworm prevention strategy, even when Stronghold has been administered monthly. This product is not effective against adult D. immitis.Treatment of ear mites (Otodectes cynotis). Cats:Treatment of biting lice infestations (Felicola subrostratusTreatment of adult roundworms (Toxocara cati)Treatment of adult intestinal hookworms (Ancylostoma tubaeforme). Dogs:Treatment of biting lice infestations (Trichodectes canis)Treatment of sarcoptic mange (caused by Sarcoptes scabiei)Treatment of adult intestinal roundworms (Toxocara canis).|For cats with, or at risk from, mixed parasitic infestations by ticks and fleas, lice, mites, gastrointestinal nematodes or heartworm.The veterinary medicinal product is exclusively indicated when use against ticks and one or more of the other target parasites is indicated at the same time.

Drugs used to treat or prevent parasitic infections. (See all compounds classified as Antiparasitic Agents.)

25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide

Selamectin Use and Manufacturing

Uses

Selamectin is a semi-synthetic avermectin derivative prepared by selective hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of endo- and exo- parasites of domestic animals, notably cats and dogs. Like the other milbemycin/avermectins, selamectin selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Veterinary drugs -> Evicto -> EMA Drug Category|Endectocides -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Chanhold -> EMA Drug Category|Antiparasitic products, insecticides and repellents -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Felisecto Plus -> EMA Drug Category|Veterinary drugs -> Stronghold -> EMA Drug Category|Antiparasitic products, insecticides and repellents, Endectocides, Macrocyclic lactones -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Stronghold Plus -> EMA Drug Category|Antiparasitic products, insecticides and repellents, Macrocyclic lactones, combinations -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:770.0
XLogP3:5.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:4
Exact Mass:769.44011183
Monoisotopic Mass:769.44011183
Topological Polar Surface Area:155
Heavy Atom Count:55
Complexity:1550
Defined Atom Stereocenter Count:14
Defined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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