Fudosteine
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Fudosteine
structure -
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CAS No:
13189-98-5
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Formula:
C6H13NO3S
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Chemical Name:
Fudosteine
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Synonyms:
L-Cysteine,S-(3-hydroxypropyl)-;Alanine,3-[(3-hydroxypropyl)thio]-,L-;Alanine,3-[(3-hydroxypropyl)thio]-;S-(3-Hydroxypropyl)-L-cysteine;S-(3-Hydroxypropyl)cysteine;(-)-3-[(3-hydroxypropyl)thio]-L-alanine;Fudosteine;SS 320A;Spelear;Cleanal;(2R)-2-Amino-3-(3-hydroxypropylsulfanyl)propanoic acid;(2R)-2-Amino-3-[(3-hydroxypropyl)sulfanyl]propanoic acid
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CAS No:
Description
Off-White PowderFudostein was launched in Japan as a new mucoactive agent for the treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in
Fudosteine is an organic molecular entity.
Characteristics
109
-3
off-white crystalline
1.301±0.06 g/cm3(Predicted)
200-202°C (dec.)
354.5±42.0 °C(Predicted)
168.2±27.9 °C
1.558
-20°C Freezer
1.92E-06mmHg at 25°C
Fudosteine Use and Manufacturing
Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Computed Properties
Molecular Weight:179.24
XLogP3:-3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:179.06161445
Monoisotopic Mass:179.06161445
Topological Polar Surface Area:109
Heavy Atom Count:11
Complexity:120
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Extract from the above information
Registered Holders
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Dijia Pharmaceutical Group Co., Ltd.
Active
China
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Zhejiang Guobang Pharmaceutical Co., Ltd.
Active
China
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Sichuan Xin Kai Yuan Pharmaceutical Co., Ltd.
Active
China
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