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2-Chlorotrityl chloride

2-Chlorotrityl chloride structure

CAS No:
42074-68-0
Formula:
C19H14Cl2
Chemical Name:
2-Chlorotrityl chloride
Synonyms:
Benzene,1-chloro-2-(chlorodiphenylmethyl)-;1-Chloro-2-(chlorodiphenylmethyl)benzene;2-Chlorophenyldiphenylmethyl chloride;o-Chlorotriphenylchloromethane;Chloro(2-chlorophenyl)diphenylmethane;Diphenyl-2-chlorophenylmethyl chloride;2-Chlorophenyldiphenylchloromethane;2-Chlorotrityl chloride;(Chloro(2-chlorophenyl)methylene)dibenzene
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

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Description

off-white to yellow or brown beads

2-Chlorotrityl chloride Basic Attributes

Molecular Weight：

313.226

Exact Mass：

313.22

EC Number：

255-647-3

DSSTox ID：

DTXSID60194914

HScode：

2903999090

Characteristics

PSA：

XLogP3：

6.2

Appearance：

Powder

Density：

1.222±0.06 g/cm3

Melting Point：

136 °C @ Solvent: Benzene

Boiling Point：

421.3°C at 760 mmHg

Flash Point：

194.2±20.9 °C

Refractive Index：

1.614

Water Solubility：

H2O: Insuluble (1.1E-4 g/L) (25 ºC)

Storage Conditions：

2-8°C

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

3261

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-24/25-22

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H290 (92.86%): May be corrosive to metals [Warning Corrosive to Metals]|P234, P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P390, and P404|Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

2-chlorotrityl chloride

2-Chlorotrityl chloride Use and Manufacturing

Methods of Manufacturing

Use o-chlorobenzoic acid and ethanol to esterify with sulfuric acid or p-toluenesulfonic acid to produce ethyl o-chlorobenzoate, and then condense with phenylmagnesium bromide (Grignard reaction) to obtain (2-chlorophenyl) di Phenyl methanol magnesium salt, the latter is hydrolyzed with sulfuric acid to obtain (2-chlorophenyl) diphenyl methanol, and then chlorinated with thionyl chloride to obtain the product.

Uses

Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.

Computed Properties

Molecular Weight:313.2
XLogP3:6.2
Rotatable Bond Count:3
Exact Mass:312.0472558
Monoisotopic Mass:312.0472558
Heavy Atom Count:21
Complexity:298
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzene

Thionyl chloride

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