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Robenidine hydrochloride

Robenidine hydrochloride structure

CAS No:
25875-50-7
Formula:
C15H13Cl2N5.ClH
Chemical Name:
Robenidine hydrochloride
Synonyms:
Carbonimidic dihydrazide,2,2′-bis[(4-chlorophenyl)methylene]-,hydrochloride (1:1);Guanidine,1,3-bis[(p-chlorobenzylidene)amino]-,monohydrochloride;Carbonimidic dihydrazide,bis[(4-chlorophenyl)methylene]-,monohydrochloride;Robenzidene;Robenidine hydrochloride;1,3-Bis[(p-chlorobenzylidene)amino]guanidine monohydrochloride;Cycostat;NCL 812;2,2′-Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride;12692-91-0
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Description

Off-White Solid

An anticoccidial agent mainly for poultry.

Robenidine hydrochloride Basic Attributes

Molecular Weight：

370.66

Exact Mass：

369.031

EC Number：

247-307-8

UNII：

8STT15Y392

Characteristics

PSA：

75.1

XLogP3：

5.15890

Appearance：

Off-White Solid

Melting Point：

289-290 °C

Boiling Point：

488.1ºC at 760 mmHg

Flash Point：

249ºC

Storage Conditions：

0-6°C

Vapor Pressure：

1.12E-09mmHg at 25°C

Safety Information

wgk germany：

hazard class code：

RTECS Number：

ME8651000

Marks：

Precautionary statement(s)：

P264, P270, P273, P301+P312, P330, P391, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (95.35%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 43 companies from 5 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

MeSH Entry Terms：

Cytostat

Robenidine hydrochloride Use and Manufacturing

Methods of Manufacturing

It is obtained from sulfamididine as raw material and cyclized with acetylacetone. Sulfamidam, acetylacetone, sodium bisulfite, sodium hydroxide and water were put into the reaction kettle and heated to reflux for about 6h. When crystallization occurs in the reaction solution, continue to reflux for 20 hours after adding acetylacetone. After recovering acetylacetone, add appropriate amount of boiling water and filter while hot. The filter cake is washed with hot water, recrystallized and dried to obtain sulfamethazine.

Uses

Robenidine is used as a coccidiostat.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:370.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:369.031479
Monoisotopic Mass:369.031479
Topological Polar Surface Area:75.1
Heavy Atom Count:23
Complexity:408
Defined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Benzaldehyde

Chlorine dioxide

Acetylacetone

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CAS No.: 25875-50-7

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Robenidine Hydrochloride

CAS No.: 25875-50-7

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