Benzethonium chloride

448.08

447.290405

3898548

204-479-9

PH41D05744

0387

755908|20200

DTXSID6023810

COLORLESS CRYSTALS

D - Dermatologicals

29239000

18.5

4.0

White Liquid

0.998 g/mL at 20 °C

164-166 °C

INDEX OF REFRACTION: 1.5101 @ 25 °C/D; INDEX OF REFRACTION FALLS ON REPETITION|INDEX OF REFRACTION: 1.560 (ALPHA), 1.565 (BETA), 1.589 (GAMMA)

H2O: 1-5 g/100 mL at 18 ºC

Store at +15°C to +25°C.

Oral-rat LD50: 368 mg/kg; Oral-Mouse LD50: 338 mg/kg

Combustible; burning produces toxic nitrogen oxides, ammonia and chloride fumes

MILD ODOR

VERY BITTER TASTE

PH OF 1% AQ SOLN IS BETWEEN 4.8 & 5.5

210.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

SPLINTERS SLIGHTLY @ 120 °C|OPTIC SIGN + ; AXIAL ANGLE 2V= 48 DEG; MOST FRAGMENTS DO NOT EXTINGUISH COMPLETELY|HYDROPHILIC PART OF MOLECULE IS POSITIVE RATHER THAN NEGATIVE; DETERGENTS RELEASE ANION (CL- OR BR-) /CATIONIC DETERGENTS/|MINERAL ACIDS & MANY SALT SOLN PPT BENZETHONIUM CHLORIDE FROM SOLN MORE CONCN THAN 2% AS OIL WHICH CRYSTALLIZES ON DRYING|For more Other Experimental Properties (Complete) data for BENZETHONIUM CHLORIDE (7 total), please visit the HSDB record page.

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble.

Ethers

BENZETHONIUM CHLORIDE is incompatible with strong oxidizing agents. Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause it to precipitate from aqueous solutions of >2% concentration. Stable for two weeks at temperatures up to 140 F, (NTP, 1992).

III

8

UN1759

2

22-37/38-41-36-36/37/38-20/21/22-50/53-34-52/53

26-36/39-24/25-36/37/39-61-45

BO7175000

Xn,N,C

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents, soap, anionic detergents, nitrates, acids. Light sensitive.

P273-P280-P301 + P310-P305 + P351 + P338-P310-P501

H301-H314-H410

INCOMPATIBILITIES: INCOMPATIBLE WITH & INACTIVATED BY SOAPS, ANIONIC DETERGENTS, ORGANIC MATERIAL, & NITRATES.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

HECHT A; STANDARDS FOR NONPRESCRIPTION GERM KILLERS. FDA CONSUM 12(JUL-AUG) 15 (1978). THE FOOD AND DRUG ADMINISTRATION'S TENTATIVE STANDARDS FOR A VARIETY OF OVER-THE-COUNTER DRUGS THAT ARE USED TO KILL GERMS ON THE SKIN ARE DISCUSSED INCL THE INGREDIENT BENZETHONIUM CHLORIDE WHICH HAS BEEN FOUND SAFE & EFFECTIVE.

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H301 (74.45%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P310, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P391, P405, and P501|Aggregated GHS information provided by 279 companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, and P501

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. Splash proof safety goggles should be worn while handling this chemical. Alternatively, a full face respirator, equipped as above, may be used to provide simultaneous eye and respiratory protection. RECOMMENDED GLOVE MATERIALS: Permeation test results for handling the neat (undiluted) chemical. If this chemical makes direct contact with your gloves, or if a tear, puncture or hole develops, replace them at once. Glove Type Model Number Thickness Bkthru Time Butyl rubber North B-174 0.64 mm 480 min. Latex Ackwell 0.18 mm 480 min. Neoprene Edmont 29-870 0.48 mm 480 min. Polyvinyl Edmont 34-100 0.20 mm 480 min. chloride Permeation Test Results of Diluted Chemical in 95% ethanol: The breakthrough times of the diluted chemical at three different concentrations are given for each glove type. If a solution of this chemical makes direct contact with your gloves, or if a tear, puncture or hole develops, replace them at once Glove Type Model Number 100 mg/mL 1.2 mg/mL 0.03 mg/mL Neoprene Edmont 29-870 480 min. Unknown 480 min. PVC Edmont 34-100 480 min. 480 min. 480 min. Unknown North 480 min. 480 min. 480 min. Silvershield (NTP, 1992)|Wear skin protection. Hot conditions may necessitate use of self-contained breathing apparatus.

Alcohol foam, carbon dioxide, dry chemical, water fog /Hyamine cmpd/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from food and feedstuffs. Store in an area without drain or sewer access. Dry.

The substance is corrosive to the eyes. The substance is irritating to the skin.

Repeated or prolonged contact with skin may cause dermatitis.

NO open flames.

Use ventilation (not if powder).

Protective gloves.

Wear safety goggles.

highly toxic

... Male and female F344/N rats and B6C3FI mice were topically administered benzethonium chloride (greater than 98% pure) for ... 2 yr. ... 2 YEAR STUDY IN RATS: Groups of 60 male and 60 female F344/N rats were topically administered 0, 0.15, 0.5, or 1.5 mg benzethonium chloride/kg body weight 5 days/wk for 103 wk. ... 2 YEAR STUDY IN MICE: Groups of 60 male and 60 female B6C3F1 mice were topically administered 0, 0.15, 0.5, or 1.5 mg benzethonium chloride/kg body weight 5 days/wk for 103 wk. Doses were administered in ethanol, and dose volumes were adjusted weekly according to the average body weights of the groups. ... CONCLUSIONS: Under the conditions of these 2 yr dermal studies, there was no evidence of carcinogenic activity of benzethonium chloride in male or female F344/N rats receiving 0.15, 0.5, or 1.5 mg/kg. There was no evidence of carcinogenic activit,v in male or female B6C3F1 mice receiving 0.15, 0.5, or 1.5 mg/kg.|Benzethonium chloride was prepared in 95% ethanol, which also served as the vehicle. A 0.5% solution of 1-fluoro-2,4-dinitrobenzene ... was used as the positive control. In the primary irritancy studies, a 10% concentration of benzethonium chloride was not significantly irritating, therefore, 20% was chosen as the challenge concentration. For the hypersensitivity test, /female/ B6C3F1 mice were divided into 7 treatment groups of 8 mice/group and administered the test compound at the concentrations shown in Table 1. The irritancy response was determined by monitoring the extravasation of 125I-bovine serum albumin into the testing area. The contact hypersensitivity response was determined by monitoring the infiltration of 125I- iododeoxyuridine labeled cells into the challenge site. ... There were no treatment-related effects on survival or body weights. The Hypersensitivity Index (HI) values obtained with benzethonium chloride sensitization at 1%, 3%, and 10% were not significantly different from the baseline control value. The positive control group (6) produced a statistically significant hypersensitivity response at a sensitizing and challenge concentration of 0.5% 1-fluoro-2,4-dinitrobenzene. ... Under these experimental conditions, no statistically significant group or dose-dependent contact hypersensitivity responses to benzethonium chloride were observed in mice by dermal exposure.

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

PERCUTANEOUS ABSORPTION IS PROBABLY INSIGNIFICANT. /BENZALKONIUM CHLORIDE/

SYMPTOMS: Symptoms of exposure to this compound may include vomiting, collapse, convulsions and coma. Other symptoms may include corrosion or injury to the mucous membranes. It may cause nausea, esophageal damage and necrosis, hypotension and death. It may also cause dyspnea, cyanosis, paralysis of respiratory muscles possibly leading to asphyxia, and central nervous system depression (possibly with convulsions or preceded by excitement). It has depolarizing muscle relaxant properties. It can cause irritation to the skin, eyes, mucous membranes and upper respiratory tract. Intravenous or intrauterine administration may cause hemolysis. ACUTE/CHRONIC HAZARDS: This compound is highly toxic by ingestion. It is also harmful by inhalation or skin absorption. It is an irritant of the skin, eyes, mucous membranes, and upper respiratory tract. When heated to decomposition this chemical emits very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride gas. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

... USED AS SPERMATOCIDES ... CAN CAUSE VAGINAL IRRITATION, WITH BURNING SENSATIONS & ITCHING.|FATAL DOSE BY INGESTION IS EST TO BE 1-3 G. AT LEAST 3 FATALITIES HAVE OCCURRED FROM ACCIDENTAL INGESTION. /CATIONIC DETERGENTS/|Ingestion may cause vomiting, collapse, convulsions, coma.|Highly toxic by ingestion; 1 gram may be fatal.

Bencetonium Chloride

The substance can be absorbed into the body through the skin and by ingestion.

Redness. Pain.

Redness. Blurred vision. Pain. Severe burns.

Aqueous solution, crystals, ethanol/water solution.|V-TERGENT 8X, DETERGENT- DEODORANT; COMPOSITION: BENZETHONIUM CHLORIDE 1.6%; ISOPROPYL ALC 13.5%. APPLICATIONS: WIDELY USEFUL DETERGENT & DEODORANT. LIQUEFIES PUS & FATTY EXUDATES.|BENZETHONIUM CHLORIDE, USP (PHEMEROL CHLORIDE), AVAIL AS 0.133 & 3% SOLN, 0.2% TINCTURE, & 0.2% VAGINAL FOAM.|GRADE: NATIONAL FORMULARY.

Benzenemethanaminium, N,N-dimethyl-N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]-, chloride (1:1): ACTIVE|THE CATIONIC DETERGENTS...SUCH AS BENZETHONIUM CHLORIDE...ARE SYNTHETIC DERIVATIVES OF AMMONIUM CHLORIDE.|A COMBINATION OF CATIONIC GERMICIDE & ANIONIC POLYMER FOR SORPTION ONTO THE TOOTH SURFACE INHIBITING CALCULUS OR PLAQUE FORMATION. BENZETHONIUM CHLORIDE IS AN INGREDIENT IN THE MOUTHWASH FORMULATION.|IT IS OF ONLY LIMITED VALUE IN TREATMENT OF FUNGUS INFECTIONS.|WHEN APPLIED TO SKIN, THEY TEND TO FORM A FILM UNDER WHICH BACTERIA MAY REMAIN VIABLE; INNER SURFACE OF FILM HAS LOW BACTERICIDAL POWER WHEREAS OUTER SURFACE IS STRONGLY BACTERICIDAL. THEY DO NOT KILL SPORES. ... ACTION IS RATHER SLOW WHEN COMPARED TO THAT OF IODINE. /QUATERNARY AMMONIUM COMPD/|For more General Manufacturing Information (Complete) data for BENZETHONIUM CHLORIDE (13 total), please visit the HSDB record page.

THIS SPECTROPHOTOMETRIC METHOD SHOWED GOOD RESULTS @ CONCN OF 0-300 UG/ML & IN THE PRESENCE OF SEVERAL DRUGS.|SPECTROPHOTOMETRIC METHOD WAS DEVELOPED TO DETECT TRACE AMT OF BENZETHONIUM, WHICH WAS EXTRACTED WITH NITROBENZENE FROM AN AQ ALKALINE SOLN. /BENZETHONIUM/|USING GLASS CAPILLARY GC AND ION-PAIR REVERSED-PHASE HPLC, BENZETHONIUM CHLORIDE AND ITS CRESOL ANALOGUE WERE EFFECTIVELY RESOLVED AND QUANTIFIED.|SURFACTANT QUATERNARY AMMONIUM SALTS ALONE OR IN PHARMACEUTICAL PREPNS, INCLUDING BENZYLTHONIUM CHLORIDE WERE DETD BY POTENTIOMETRIC TITRATION OF AQ SOLN.|For more Analytic Laboratory Methods (Complete) data for BENZETHONIUM CHLORIDE (7 total), please visit the HSDB record page.

Cosmetics -> Preservative