Esomeprazole magnesium
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Esomeprazole magnesium
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CAS No:
217087-09-7
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Formula:
C17-H19-N3-O3-S.Na
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Chemical Name:
Esomeprazole magnesium
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CAS No:
Description
Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in
Characteristics
163
6.90950
off-white powder
184-189°C (dec.)
600°C at 760 mmHg
316.7ºC
-20°C Freezer
2.35E-14mmHg at 25°C
Drug Function and Efficacy
Esomeprazole is the S-isomer of omeprazole and acts as a specific inhibitor of the H+/K+-ATPase enzyme (the proton pump) in gastric parietal cells. It reduces gastric acid secretion by targeting this pump, thereby inhibiting both basal and stimulated acid secretion. It is used to treat conditions related to excessive gastric acid such as GERD, erosive esophagitis, and peptic ulcers, and to eradicate Helicobacter pylori when combined with antibiotics.
Registered Holders
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METROCHEM API PRIVATE LTD
Active
United States
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SRINI PHARMACEUTICALS PRIVATE LTD
Active
United States
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CHROMO LABORATORIES INDIA PRIVATE LTD
Active
United States
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