Calcium lactate

218.22

218.01

212-406-7

DTXSID0020236

White, crystalline powder

A - Alimentary tract and metabolism

2918110000

121

-3.76580

DryPowder

> 120

227.6ºC at 760 mmHg

109.9ºC

INDEX OF REFRACTION: 1.470 (ALPHA), 1.510 (GAMMA); ELONGATION: +, EXTINCTION PARALLEL

Sol in water

Calcium lactate can exist in a number of hydration states, which are characterized as anhydrous, monohydrate, trihydrate, and pentahydrate. Dehydration of the pentahydrate form is rapid at temperatures of 558℃ and above. Dehydration is reported to be accompanied by some loss of crystallinity. Tablet crushing strength was reported to be reduced following dehydration of calcium lactate pentahydrate.

Intravenous-Mouse LD50: 140 mg/kg

Thermal decomposition spicy irritating smoke

Between 6,0 and 8,0 (5 % solution)

36/37/38

26-36/37/39

Warehouse ventilated, low temperature and dry

AQ SOLN ARE PRONE TO BECOME MOLDY.

P264, P280, P305+P351+P338, P33, P313

H319

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).|Calcium lactate used as a general purpose food additive is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

|Warning|H319 (98.75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 87 companies from 4 notifications to the ECHA C&L Inventory.|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|Aggregated GHS information provided by 33 companies from 2 notifications to the ECHA C&L Inventory.|Danger|H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310|Aggregated GHS information provided by 35 companies from 1 notifications to the ECHA C&L Inventory.

moderately toxic

The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg [MSDS].

IN TREATMENT OF TETANY, ITS ABSORPTION IS APPARENTLY ENHANCED BY SIMULTANEOUS ADMIN OF LACTOSE.

No pharmacokinetic data available.

Indicated for use as the nutritional supplement.

EXPTL USE: ORAL ADMIN OF CALCIUM LACTATE (7.7 G) LOWERED PLASMA PARATHYROID HORMONE BY 40-43% & DECR URINARY EXCRETION OF CYCLIC ADENOSINE MONOPHOSPHATE BY 30-54% IN SKELETAL-TYPE HYPERPARATHYROIDISM BUT NOT IN OTHER TYPES OR IN CONTROLS.|EXPTL USE: HIGH DOSES OF ORAL CALCIUM LACTATE DECR URINARY CYCLIC ADENOSINE MONOPHOSPHATE EXCRETION IN BORDERLINE CASES OF UROLITHIC AND CHEM HYPERPARATHYROIDISM.|May be used to treat mild hypocalcemia and for maintenance therapy. /From table/|MEDICATION (VET): IN CALCIUM THERAPY

CALCIUM GLUCONATE & BOROGLUCONATE ARE CONSIDERED TO BE SIGNIFICANTLY LESS TOXIC THAN THE LACTATE OR THE CHLORIDE.

Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively.

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport.|Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours.|The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity.|No pharmacokinetic data available.

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle.|RUMINAL INGESTA FROM COWS FED 2.5 L GRAIN-ALFALFA HAY MIXT PROVIDING 545 G OF SODIUM LACTATE & CALCIUM LACTATE DAILY INCUBATED WITH SODIUM LACTATE OR 17 POLY LACTIC ACID. ACETATE WAS PRIMARY END PRODUCT BUT OXIDN OF LACTATE CAUSED SYNTH OF BUTYRATE FROM ACETATE.

No pharmacokinetic data available.

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis.

Ca lactate

CALCIUM LACTATE USP; POWDER USP, TABLETS USP, 325 MG (42.25 MG CALCIUM), & 650 MG (84.5 MG CALCIUM)|Commercial prepn usually contains about 25% water, and on the anhydrous basis it is at least 98% pure.|GRADES: NF; FCC.

Agriculture, forestry, fishing and hunting|Propanoic acid, 2-hydroxy-, calcium salt (2:1): ACTIVE|Commercial baking powder contains 2.5% calcium lactate.

CALCIUM LACTATE COMPOSITIONS CONTAIN 36% CALCIUM BOUND IN COMPLEXES. TOTAL CALCIUM CONCN WAS DETERMINED BY POTENTIOMETRIC TITRATION USING CALCIUM SELECTIVE ELECTRODES.

Food additives|Food Additives -> ACIDITY_REGULATOR; FLOUR_TREATMENT_AGENT; YEAST_FOOD; -> JECFA Functional Classes|Cosmetics -> Buffering

Food Additives -> ACIDITY_REGULATOR; FLOUR_TREATMENT_AGENT; YEAST_FOOD;