Glycerides, mixed decanoyl and octanoyl
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Glycerides, mixed decanoyl and octanoyl
structure -
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CAS No:
73398-61-5
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Chemical Name:
Glycerides, mixed decanoyl and octanoyl
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Synonyms:
Glycerides,mixed decanoyl and octanoyl
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CAS No:
Description
A colorless to slightly yellowish oily liquid that is practically odorless and tasteless. It solidifies at about 0°C. The oil is free from catalytic residues or the products of cracking.
Liquid
Characteristics
107
6
Liquid
0.94-0.96
storage temperatures that can be experienced in tropical and
temperate climates. Ideally, however, they should be stored at
temperatures not exceeding 25°C and not exposed to temperatures
above 40°C for long periods. At low temperatures, samples of
medium-chain triglycerides may become viscous or solidify.
Samples should therefore be well melted and mixed before use,
although overheating should be avoided.
In the preparation of microemulsions and self-emulsifying
systems, emulsions, or aqu
Safety Information
P264, P273, P280, P305+P351+P338, P337+P313, P391, P501
H319
|Warning|H319 (69.53%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P273, P280, P305+P351+P338, P337+P313, P391, and P501|Aggregated GHS information provided by 720 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Glycerides, mixed decanoyl and octanoyl Use and Manufacturing
Medium-chain triglycerides have been used in a variety of
pharmaceutical formulations including oral, parenteral, and topical
preparations.
In oral formulations, medium-chain triglycerides are used as the
base for the preparation of oral emulsions, microemulsions, selfemulsifying
systems, solutions, or suspensions of drugs that are
unstable or insoluble in aqueous media, e.g. calciferol. Mediumchain
triglycerides have also been investigated as intestinalabsorption
enhancersand have additionally been used as a
filler in capsules and sugar-coated tablets, and as a lubricant or
antiadhesion agent in tablets.
In parenteral formulations, medium-chain triglycerides have
similarly been used in the production of emulsions, solutions, or
suspensions intended for intravenous administration.In rectal
formulations, medium-chain triglycerides have been used in the
preparation of suppositories containing labile materials. In cosmeticsand topical pharmaceutical preparations, medium-chain
triglycerides are used as a component of ointments, creams, and
liquid emulsions.
Therapeutically, medium-chain triglycerides have been used as
nutritional agents.Diets containing medium-chain triglycerides
are used in conditions associated with the malabsorption of fat,
such as cystic fibrosis, since medium-chain triglycerides are more
readily digested than long-chain triglycerides. Medium-chain
triglycerides have been particularly investigated for their use in
total parenteral nutrition (TPN) regimens in combination with longchain
triglycerides.
Although similar to long-chain triglycerides, medium-chain
triglycerides have a number of advantages in pharmaceutical
formulations, which include better spreading properties on the
skin; no impedance of skin respiration; good penetration properties;
good emollient and cosmetic properties; no visible film on the skin
surface; good compatibility; good solvent properties; and good
stability against oxidation.
Intermediates
Air care products
1,000,000 - 10,000,000 lb
All other chemical product and preparation manufacturing|Glycerides, mixed decanoyl and octanoyl: ACTIVE
EPA Safer Chemical Functional Use Classes -> Solvents|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Emollient; Emulsifying; Solvent
Computed Properties
Molecular Weight:387.5
XLogP3:6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:19
Exact Mass:387.27466396
Monoisotopic Mass:387.27466396
Topological Polar Surface Area:107
Heavy Atom Count:27
Formal Charge:-1
Complexity:366
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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