Magnesium acetate tetrahydrate
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Magnesium acetate tetrahydrate
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CAS No:
16674-78-5
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Formula:
C2H4O2.2H2O.1/2Mg
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Chemical Name:
Magnesium acetate tetrahydrate
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Synonyms:
Acetic acid,magnesium salt,hydrate (2:1:4);Acetic acid,magnesium salt,tetrahydrate;Magnesium acetate tetrahydrate;Magnesium diacetate tetrahydrate;Magnesium acetate (Mg(OAc)2) tetrahydrate;Magnesium(2+) acetate tetrahydrate
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CAS No:
Description
Colourless crystals or white or almost white, crystalline powder.Anhydrous magnesium sulfate is a white crystalline solid occurring in alpha form as orthorhomic crystals or as a beta form having triclinic structure; density 1.507 and 1.502 g/cm3 for alphaand beta-forms, respectively; decomposes at 323°C; very soluble in water; moderately soluble in methanol (5.25g/100 mL at 15°C). The tetrahydrate constitutes colorless monoclinic crystals; hygroscopic; density 1.454 g/cm3; melts at 80°C;
Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second most abundant cation in the body that plays a key role in maintaining normal cellular function such as production of ATP and efficient enzyme activity. Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments.|Magnesium Acetate Tetrahydrate is the hydrated acetate salt form of magnesium. Magnesium is a divalent cation essential for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions. About 350 enzymes involved in glycolysis and the Krebs cycle, formation of cyclic-AMP and ATP, cellular signal transduction and protein and nucleic acid synthesis are dependent on magnesium.
Magnesium acetate tetrahydrate Basic Attributes
214.45
214.05400
205-554-9
I01G0EJC3B
DTXSID60168170
C48001
29152900
Characteristics
84.3
-2.74480
White lyophilized powder
1.454
72-75 °C(lit.)
117.1
n 20/D 1.358
H2O: 1 M at 20 °C, clear, colorless
−20°C
13.9mmHg at 25°C
Safety Information
NONH for all modes of transport
3
22-24/25
AI5600000
Stable under normal temperatures and pressures.
Toxicity
Predicted oral LD50 value is >2000mg/kg. In case of mild to moderate toxicity, it may cause irritation in case of skin or eye contact,and nausea or vomiting from ingestion and inhalation. In overdose, magnesium impairs neuromuscular transmission, manifested as weakness and hyporeflexia. Early manifestations of severe toxicity are lethargy, hyporeflexia, followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures, and respiratory depression.
Protein binding of magnesium ions is about 30%
Drug Information
Used as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention. Magnesium acetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy.|Parenteral nutrition
Magnesium is an essential cofactor for many enzymatic reactions such as protein synthesis and ATP production. It also participates in adenylyl cyclase pathway and tyrosine kinase signalling pathways. Magnesium may also play a role in regulating glucose metabolism. It serves as an essential cation for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions.
Intestinal absorption is achieved mainly through passive diffusion.|Mainly renal exctretion, where up to 97% of magnesium may be excreted renally during hypermagnesemia.|Magnesium ions display approximate volume of distribution of 0.2 to 0.4 L/kg
Elimination half-life has been reported to be 27.7 hours following an overdose of 400mEq magnesium in an adult.
Magnesium ions electrostatically stabilize the adenylyl cyclase complex and enhance its catalytic actions and production of cAMP. They also regulate the level of phosphorylation in various pathways by formation of transition state of phosphoryl transfer reaction by protein kinases and stabilize ATP binding to protein kinases via electrostatic interactions. Many metabolic enzymes involved in glycolysis and Krebs cycle are magnesium-dependent. Magnesium-containing laxatives cause diarrhea through water retention and increased fecal mass that stimulates peristalsis. When used as an electrolyte supplementation, magnesium acetate tetrahydrate induces diuresis and metabolic alkalinizing effect. Magnesium ions enhance reactivity of arteries to vasoconstrictors, promotes vasoconstriction, and increases peripheral resistance, leading to increased blood pressure through potential competition with calcium ions in the vascular system. Magnesium ions also regulate other ions entering and exiting the cell membrane by acting as a ligand in N-methyl-D-aspartate receptor.
Magnesium acetate tetrahydrate Use and Manufacturing
Derived from the reaction of magnesium carbonate and acetic acid. Add 80% acetic acid to water, heat to 60-80°C, and add magnesium carbonate in small portions until the carbon dioxide no longer escapes. The solution was placed on a water bath, heated and concentrated to a relative density of 1.25-1.26, and cooled. The crystals were filtered out to obtain magnesium acetate tetrahydrate.
Magnesium acetate tetrahydrate is used in the manufacture of rayon fiber for cigarette filters; and as a fixative for dyes in textile printing. It also is used as an antiseptic and disinfectant. Used in dialysis solutions. Magnesium acetate [Mg(C2H3O2)2'4H2O] is used in the textile industry as a mordant (“fixes” dyes so that they will not run). It is also used as a deodorant and antiseptic.
EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:214.45
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Exact Mass:214.0539091
Monoisotopic Mass:214.0539091
Topological Polar Surface Area:84.3
Heavy Atom Count:13
Complexity:25.5
Covalently-Bonded Unit Count:7
Compound Is Canonicalized:Yes
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