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Flunixin

Flunixin structure

CAS No:
38677-85-9
Formula:
C14H11F3N2O2
Chemical Name:
Flunixin
Synonyms:
3-Pyridinecarboxylic acid,2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-;2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid;Flunixin;2-(2-Methyl-3-trifluoromethylanilino)nicotinic acid;Sch 14714
Categories:
Organic Chemistry > Amides

Description

Crystalline Solid

Flunixin is a pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs. It has a role as a non-steroidal anti-inflammatory drug, an antipyretic, a non-narcotic analgesic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a pyridinemonocarboxylic acid, an aminopyridine and an organofluorine compound. It derives from a nicotinic acid. It is a conjugate acid of a flunixin(1-).|Flunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form. Flunixin is regulated in the United States by the Food and Drug Administration (FDA) and must be prescribed by a licensed veterinarian. Flunixin may be also referred to as Banamine, and other trade names.

Flunixin Basic Attributes

Molecular Weight：

296.25

Exact Mass：

296.24

EC Number：

609-571-6

UNII：

356IB1O400

DSSTox ID：

DTXSID4048565

HScode：

2933399090

Characteristics

PSA：

62.2

XLogP3：

3.92360

Appearance：

off-white solid

Density：

1.403g/cm3

Melting Point：

226-228 °C

Boiling Point：

378.7ºC at 760 mmHg

Flash Point：

182.8ºC

Refractive Index：

1.582

Water Solubility：

H2O: freely soluble

Collision Cross Section：

159.1 Å² [M+H]+ [CCS Type: TW]

Safety Information

Transport codes：

UN28116.1/PG3

wgk germany：

hazard class code：

36/37/38-22

safety instructions：

26-36

RTECS Number：

LZ4367000

Marks：

Xi,Xn

Stability/Shelf Life：

Stable. Incompatible with strong bases, strong oxidizing agents.

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (93.02%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 43 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Drugs that are used to reduce body temperature in fever. (See all compounds classified as Antipyretics.)

MeSH Entry Terms：

flunixin

Flunixin Use and Manufacturing

Uses

Cyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Computed Properties

Molecular Weight:296.24
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:296.07726208
Monoisotopic Mass:296.07726208
Topological Polar Surface Area:62.2
Heavy Atom Count:21
Complexity:376
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes