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Flunixin meglumine

Flunixin meglumine structure

CAS No:
42461-84-7
Formula:
C14H11F3N2O2.C7H17NO5
Chemical Name:
Flunixin meglumine
Synonyms:
D-Glucitol,1-deoxy-1-(methylamino)-,2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (1:1);D-Glucitol,1-deoxy-1-(methylamino)-,2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (salt);3-Pyridinecarboxylic acid,2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-,compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1);2-(2-Methyl-3-trifluoromethylanilino)nicotinic acid N-methyl-D-glucamine salt;Banamine;Flunixin meglumine;Flunixin N-methylglucamine;Finadyne;NIH 10250;Ilium flunixil;Equileve;Flunimeg;Finadyne RP;54396-43-9
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Target: COXFlunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when

Flunixin meglumine is an organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs. It has a role as an antipyretic, a non-narcotic analgesic, a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It contains a flunixin(1-).

Flunixin meglumine Basic Attributes

Molecular Weight：

491.45800

Exact Mass：

491.18800

EC Number：

255-836-0

UNII：

8Y3JK0JW3U

NSC Number：

759583

DSSTox ID：

DTXSID1045584

HScode：

29339900

Characteristics

PSA：

175.40000

XLogP3：

0.95620

Appearance：

solid

Density：

1.403 g/cm3

Melting Point：

135-139 °C

Boiling Point：

378.7ºC at 760 mmHg

Flash Point：

182.8ºC

Water Solubility：

H2O: freely soluble

Storage Conditions：

0-6ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36

RTECS Number：

LZ4367000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Danger|H301 (79.51%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P314, P320, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 206 companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Drugs that are used to reduce body temperature in fever. (See all compounds classified as Antipyretics.)

MeSH Entry Terms：

Banamine

Flunixin meglumine Use and Manufacturing

Uses

1. Dental carries prophylactic
2. Cyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:491.5
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:9
Exact Mass:491.18793473
Monoisotopic Mass:491.18793473
Topological Polar Surface Area:175
Heavy Atom Count:34
Complexity:510
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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