α-Naphthylthiourea Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Antu |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Rattrack; 1-naphthalenylthiourea; 1-(1-naphthyl)thiourea |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research uses. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Carcinogenicity, Category 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H300 Fatal if swallowed H351 Suspected of causing cancer |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
| Response | P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Antu | Antu | 86-88-4 | 201-706-3 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Treatment includes gastrointestinal decontamination with activated charcoal, supportive care, and monitoring of electrolytes and glucose. Pulmonary edema may be delayed up to 72 hours. Patients ingesting more than 5 mg/kg body weight should be admitted for observation.
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. Naphthylthiourea
5.2 Specific hazards arising from the chemical
Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. It reacts with silver nitrate and strong oxidizers. Avoid decomposing heat. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Ventilate area of spill. For small quantities, sweep onto paper or other suitable material, place in appropriate container and burn in safe place (such as fume hood). Large quantities may be reclaimed ... If not practical, dissolve in flammable solvent ... and atomize in ... combustion chamber ...
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants, silver nitrate and food and feedstuffs.Separated from strong oxidants, silver nitrate, food and feedstuffs.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: 0.3 mg/m3, as TWA; (skin); A4 (not classifiable as a human carcinogen).MAK: skin absorption (H); carcinogen category: 3B
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles, face shield or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Antu is a white crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S. (EPA, 1998) |
|---|---|
| Colour | Prisms from alcohol |
| Odour | Odorless |
| Melting point/freezing point | 193ºC |
| Boiling point or initial boiling point and boiling range | 377.6ºC at 760 mmHg |
| Flammability | Noncombustible Solid |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 182.1ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | 0.06 % (NIOSH, 2016) |
| Partition coefficient n-octanol/water | log Kow = 1.65 |
| Vapour pressure | 0 mm Hg at 77° F (EPA, 1998) |
| Density and/or relative density | 1.333 g/cm3 |
| Relative vapour density | 6.99 (EPA, 1998) (Relative to Air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on heating. This produces toxic gases and toxic fumes including nitrogen oxides, sulfur oxides and carbon monoxide. Reacts with strong oxidants such as silver nitrate. This generates fire and explosion hazard.
10.2 Chemical stability
Stable on exposure to air and to sunlight.
10.3 Possibility of hazardous reactions
To fight fire use:/Powder, water spray, foam, carbon dioxide.ANTU is incompatible with the following: Strong oxidizers, silver nitrate (NIOSH, 2016).
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatibilities: Contact with strong oxidizers may cause fires and explosions.
10.6 Hazardous decomposition products
Hazardous decomposition products include: sulfur dioxide, oxides of nitrogen, and carbon monoxide.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 3 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
EVALUATION: The available data were inadequate to evaluate the carcinogenicity of 1-naphthylthiourea to exptl animals. No data on humans were avail. The avail data are insufficient to evaluate the carcinogenicity of 1-naphthylthiourea to humans.
Reproductive toxicity
no data available
STOT-single exposure
Exposure could cause lung oedema. Medical observation is indicated.
STOT-repeated exposure
no data available
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
An estimated BCF of 5.7 was calculated in fish for alpha-naphthylthiourea(SRC), using a log Kow of 1.65(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of alpha-naphthylthiourea can be estimated to be 3600(SRC). According to a classification scheme(2), this estimated Koc value suggests that alpha-naphthylthiourea is expected to have slight mobility in soil. The pKa of alpha-naphthylthiourea is estimated as 9.47(3), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2902 (For reference only, please check.) | IMDG: UN2902 (For reference only, please check.) | IATA: UN2902 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: PESTICIDE, LIQUID, TOXIC, N.O.S. (For reference only, please check.) | IMDG: PESTICIDE, LIQUID, TOXIC, N.O.S. (For reference only, please check.) | IATA: PESTICIDE, LIQUID, TOXIC, N.O.S. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: I (For reference only, please check.) | IMDG: I (For reference only, please check.) | IATA: I (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Antu | Antu | 86-88-4 | 201-706-3 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Commonly present impurities can change the toxicological properties of this substance; consult an expert.Technical product is a blue-grey powder.Temperature of decomposition is unknown in the literature.Do NOT take working clothes home.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
α-Naphthylthiourea is included in Other Chemical Drugs category.
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