2-Chloroaniline Safety Data Sheets

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Eye irritation, Category 2

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound may include headache, nausea, vomiting, jaundice, convulsions, severe kidney damage, liver damage, methemoglobin formation and in sufficient concentrations, cyanosis; skin and eye irritation; and dermatitis. Onset may be delayed 2-4 hours or longer. ACUTE/CHRONIC HAZARDS: This compound is toxic by ingestion, inhalation and contact with the skin. It may cause irritation of the skin. (NTP, 1992)

This chemical is combustible. (NTP, 1992)

Use powder. Use foam. Use carbon dioxide.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. Keep in the dark. Well closed.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on burning. This produces toxic fumes including nitrogen oxides and hydrogen chloride (see ICSC 0163).

Darkens on exposure to air.

O-CHLOROANILINE is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. (NTP, 1992)

no data available

Darkens with exposure to air. (TOXNET HSDB)

When heated to decomposition, it emits toxic fumes of /hydrogen chloride and nitrogen oxides/.

Acute toxicity

• Oral: LD50 Mouse oral 256 mg/kg
• Inhalation: LC50 Rat inhalation 4000-6000 mg/cu m/4 hr
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Poecilia reticulata - 6.25 mg/L - 14 d.
• Toxicity to daphnia and other aquatic invertebrates: LC50 - Daphnia magna - 0.13 mg/L - 48 h.
• Toxicity to algae: EC50 - Scenedesmus pannonicus - 32 mg/L - 72 h.
• Toxicity to microorganisms: EC50 - activated sludge - > 27 mg/L - 7 d. Remarks:Respiration rate.

AEROBIC: The results of biodegradability screening studies for 2-chloroaniline are conflicting with results ranging from no degradation to rapid degradation using soil, sewage, activated sludge and fresh water inocula(SRC). 2-Chloroaniline was found to be resistant to microbial degradation using the standard biodegradability test of the Japanese Ministry International Trade and Industry (MITI), a BOD test utilizing a mixed inoculum of activated sludge, sewage, and surface water(1,2). Only 2.7% of the 2-chloroaniline (100 ppm) degraded in a 2-week period in the MITI test(2). A 36% BODT was measured over a 190 hour incubation period with a Warburg respirometer(3). Half-lives greatly in excess of 4 weeks in both adapted and non-adapted inoculum were observed using the Repetitive Die Away (semistatic system) and Pitter (dynamic system) tests(4). No biodegradation was observed using modified procedures of the OECD and MITI test methods(5,6). Results of standard biodegradation tests were reported as follows: Coupled units, 5-6% DOC removal; Zahn-Wellens, 94% DOC removal; MITI, 0% BODT; Sturm, 0% CO2 evolution, 9% DOC removal; Closed bottle, 0% BODT(7). Another investigator obtained 85% DOC removal in 11 days in the Zahn-Wellens test(8). 2-Chloroaniline (2 mg/L) was found to be not readily biodegradable with a 10% BOD observed after 5 days in a mixed inoculum of river water collected from the Songhua River in China(9). Incubation of 2-chloroaniline in soil for 14 days resulted in formation of dichloroazobenzene, but no dichloroazobenzene was formed using sterilized soil(10). 100% loss of UV absorbance by microbial degradation in a mineral salts solution, with a soil inoculum, required an excess of 64 days(11). When 2-chloroaniline (3 ppm) was incubated in Guelph loam with water added to 60% water-holding capacity, levels declined rapidly for 2 weeks after which time the rate of loss decreased(12). The percent of 2-chloroaniline remaining in soil after 2 and 8 weeks were 40 and 20%, respectively(12).

The average BCFs in the whole body of carp exposed to 2-chloroaniline in flow-through experiments (25 deg C, 12L/hr) for 24 to 336 hours at high (16.1 ug/L) and low (0.83 ug/L) exposure levels were 2.0 and 3.7, respectively(1). Uptake was rapid in static tests (0.19 umol/L, 26 deg C) on zebrafish and a BCF of 15.3 was obtained for 24 hour exposure(2). Log BCF of 2-chloroaniline in fish were experimentally determined to be less than 2.0 using the Japanese MITI test procedures(3). In an 8-week test performed at two concentration levels, the BCF of 2-chloroaniline in carp was 5.4-9.0 (0.1 ppm) and <14-32 (0.01 ppm)(4). According to a classification scheme(5), these BCF values suggest that bioconcentration in aquatic organisms is low(SRC), provided the compound is not altered physically or chemically once released into the environment.

The Koc of 2-chloroaniline is estimated as 260(SRC), using a log Kow of 1.9(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-chloroaniline is expected to have moderate mobility in soil. However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Stabilized with 0.1% Hydrazine hydrate.Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.