2-(Thiocyanomethylthio)benzothiazole Safety Data Sheets

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Skin sensitization, Category 1

Acute toxicity - Category 2, Inhalation

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

no data available

Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion if formulations contain flammable/explosive solvents.

Use water spray, powder, foam, carbon dioxide.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating. This produces toxic fumes including hydrogen cyanide, nitrogen oxides and sulfur oxides.

no data available

Decomposes on heating. This produces toxic fumes including hydrogen cyanide, nitrogen oxides and sulfur oxides.

no data available

no data available

When heated to decomposition it emits toxic fumes of ... /sulfur oxides & nitrogen oxides/.

Acute toxicity

• Oral: LD50 Rat oral 1,590 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: /Lepomis macrochirus/ (Bluegill sunfish); Concentration: 0.047 ppm for 96 hr /60% formulation (Busan 72)/ /Conditions of bioassay not specified
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 23 ug/L for 48 hr (95% confidence interval: 20-26 ug/L); Effect: intoxication, immobilization /80% purity
• Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Algae); Conditions: freshwater, static, 25 deg C; Concentration: 39 ug/L for 30 hr; Effect: population abundance /100% purity
• Toxicity to microorganisms: no data available

AEROBIC: 2-(Thiocyanomethylthio)benzothiazole, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test classifying the compound as not readily biodegradable(1). By contrast, thiocyanic acid, (2-benzothiazolylthio) methyl ester, at an initial concentration of 42 umol/L, was 95% degraded in 9 to 12 days using a mixed culture pilot plant designed for treatment of tannery wastes; 2-(methylthio)benzothiazole was the main product(2). Using OECD Method 301B (CO2 Evolution Modified Sturm Test), 96% of initial 2-(thiocyanomethylthio)benzothiazole degraded by day 28(3); however, it took >10 days for the degradation to increase from 10 to 60%, thereby classifying the compound as not readily biodegradable under the conditions of the test(3). Soil samples were incubated in the dark with the test compound at 25 deg C for 58 days; a soil aerobic metabolism half-life of 1.4 days was reported(3).

Using carp (Cyprinus carpio) which were exposed over an 8-week period, a BCF range was of <14-20 and <153 to 268 was measured for 2-(thiocyanomethylthio)benzothiazole at concentrations of 2 and 0.2 ug/L, respectively(1). Using bluegill sunfish (Lepomis macrochirus) and a 28-day exposure period, BCF values of 44 and 184 were determined in the fillet and whole fish respectively(2). According to a classification scheme(3), BCF values of <30 are low, 30-100 are moderate and from 100 to 1,000 are high(SRC).

The adsorption of 2-(thiocyanomethylthio)benzothiazole was measured in five different soil types (sand, sandy loam, silt loam, clay and clay loam) with resulting Koc values ranging from 282 to 7896(1). Two soil adsorption studies conducted using OECD guidelines in four soil types determined Koc values of 633, 1,730, 2,060 and 2,270(2). According to a classification scheme(3), these Koc values suggest that 2-(thiocyanomethylthio)benzothiazole is expected to have moderate to no mobility in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).Carrier solvent may enhance the skin absorption.Carrier solvents used in commercial formulations may change physical and toxicological properties.