2-Nitropropane Safety Data Sheets

Flammable liquids, Category 3

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Inhalation

Carcinogenicity, Category 1B

If inhaled

Following skin contact

Following eye contact

Following ingestion

Inhalation causes respiratory tract irritation, headache, dizziness, nausea, and diarrhea. Ingestion causes irritation of mouth and stomach. Contact with liquid irritates eyes and causes mild irritation of skin. (USCG, 1999)

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire. (USCG, 1999)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Evacuate danger area! Consult an expert! Personal protection: self-contained breathing apparatus. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuate danger area! Consult an expert! Personal protection: self-contained breathing apparatus. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

After covering the spills with soda ash, mix and spray with water. Scoop into a bucket of water and leave it stand for two hours. Neutralize with 6M-hydrochloric acid and pass into drain with sufficient water.

NO open flames, NO sparks and NO smoking. Above 24°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from strong bases, strong acids, amines, powdered metals and food and feedstuffs.Store in a cool, dry, well ventilated location. Separate from amines, alkalies, acids, oxidizing materials, metal oxides, and combustibles. Outside or detached storage is preferred nitropropanes

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

100 ppm; NIOSH considers 2-nitropropane to be a potential occupational carcinogen.

Decomposes on burning. This produces toxic fumes including nitrogen oxides. Mixtures with acids, amines, inorganic bases and heavy metal oxides are shock-sensitive. Attacks some forms of plastic, rubber and coatings.

It is stable under ordinary circumstances, but may undergo explosive decomposition under conditions of extreme shock combined with heavy confinement and elevated temperature.

A very dangerous fire hazard when exposed to heat, open flame or oxidizers.2-NITROPROPANE is sensitive to heat. Can react with amines/heavy metal oxides, strong acids, strong alkalis, and chlorosulfonic acid. (NTP, 1992). The heat of adsorption of this compound on carbon, such as that found in cartridge respirators, is extremely high. Metal oxide catalysts, such as copper oxide or manganese oxide, can initiate ignition, therefore carbon respirators should not be used in environments that have a high vapor concentration of this material.

no data available

Mixing oleum and 2-nitropropane in a closed container caused the temperature and pressure to increase.

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

Acute toxicity

• Oral: LD50 Sprague-Dawley Rat oral 720 mg/kg
• Inhalation: LC50 Sprague-Dawley Rat (male) inhalation 400 ppm/6 hr
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Pimephales promelas - > 612.5 mg/L - 96 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 19 mg/L - 48 h.
• Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 887 mg/L - 72 h.
• Toxicity to microorganisms: EC50 - activated sludge of a predominantly domestic sewage - 310 mg/L - 30 min. Remarks:Respiration rate.

AEROBIC: 2-Nitropropane, present at 2.0 and 9.9 mg/L, reached 14 and 8% of its theoretical BOD, respectively in 4 weeks using an activated sludge inoculum at 2 mg/L and a closed bottle test(1). When 2-nitropropane was incubated with activated sludge, 0.8% mineralization occurred in 5 days(2,3). During a closed bottle biodegradability test, using a municipal sewage plant effluent innoculum, 0.1% degradation of 2-nitropropane occurred within 28 days(2,3). Aerobic C14 studies performed with soil microorganisms resulted in 3.0% conversion to CO2 in 35 days(2,3). During this time 28.8% was lost as volatile products during the aerobic studies(2,3). Half-lives of 2-nitropropane measured during aerobic batch laboratory microcosm experiments were 0.66 days in an acid clay soil (0.94% OC, pH 4.8) and 0.5 days in a basic sandy loam soil (3.25% OC, pH 7.8)(4,5). However, experiments were not corrected for potential loss due to volatilization(4,5).

A BCF value of 1 was measured for fish (Golden ide) in a static 3-day test with 2-nitropropane present at 50 ppb(1). BCF values of <0.9-1.1 and <8.4 were determined using orange-red killifish (Oryzias latipes) which were exposed over an 8-week period(2). According to a classification scheme(3), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

Based on Freundlich adsorption constants of 0.99354 for a Texas sandy silt loam soil (3.25% OC, pH 7.8) and 0.354 for a Mississippi sandy loam soil (0.94% OC, pH 4.8), Koc values determined for these two soils are 0.11 and 3.8, respectively(1). According to a classification scheme(2), these Koc values suggest that 2-nitropropane is expected to have very high mobility in soil. The pKa of 2-nitropropane is 7.68(3), indicating that this compound will partially exist in anion form in the environment and anions generally do not adsorb more strongly to organic carbon and clay than their neutral counterparts(4).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.The odour warning when the exposure limit value is exceeded is insufficient.Do NOT take working clothes home.