Bis(2-chloroethyl) ether Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Bis(2-chloroethyl) ether |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 2,2'-Dichlorodiethyl Ether; Bis(2-Chloroethyl)ether; 1-chloro-2-(2-chloroethoxy)ethane |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Nitrosamines/ethers/alcohols |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Acute toxicity - Category 1, Dermal
Acute toxicity - Category 2, Inhalation
Carcinogenicity, Category 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H300 Fatal if swallowed H310 Fatal in contact with skin H330 Fatal if inhaled H351 Suspected of causing cancer |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P203 Obtain, read and follow all safety instructions before use. |
| Response | P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P318 IF exposed or concerned, get medical advice. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Bis(2-chloroethyl) ether | Bis(2-chloroethyl) ether | 111-44-4 | 203-870-1 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Half-upright position. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
This material is very toxic; the probable oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 ounce for a 150 pound person. It can be a central nervous system depressant in high concentrations. It is extremely irritating to the eyes, nose, and respiratory passages. It can penetrate the skin to cause serious and even fatal poisoning. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Treat frostbite by rapid rewarming . Ethers and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Water, foam, mist, fog, spray, dry chemical.
5.2 Specific hazards arising from the chemical
May form phosgene or hydrogen chloride in fires. There is danger of explosion when ethers are heated or exposed to flames or sparks. Ethers tend to form peroxides; when ethers containing peroxides are heated, they can detonate. May be ignited by heat, sparks, or flames. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Decomposes in the presence of moisture to form hydrochloric acid. Emits toxic fumes when heated to decomposition. Reacts vigorously with oleum and chlorosulfonic acid. Ethers tend to form peroxides upon standing. Heating peroxide-containing ethers can cause detonation. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water. NO direct contact with water.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: chemical protection suit. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
1. remove all ignition sources. 2. ventilate area of spill or leak. 3. for small quantities, absorb on paper towels. evaporate in a safe place (such as a fume hood). allow sufficient time for evaporating vapors to completely clear the hood ductwork. burn the paper in a suitable location away from combustible materials. large quantities can be reclaimed.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 55°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from food and feedstuffs. See Chemical Dangers. Keep in the dark. Well closed.Store in a cool, dry, well-ventilated location. Store away form heat, oxidizing materials, strong acids, & sunlight.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: 5 ppm as TWA; 10 ppm as STEL; (skin); A4 (not classifiable as a human carcinogen).MAK: 59 mg/m3, 10 ppm; peak limitation category: I(1); skin absorption (H)
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. Liquid. |
|---|---|
| Colour | Colourless. |
| Odour | PUNGENT |
| Melting point/freezing point | -51.9 °C. |
| Boiling point or initial boiling point and boiling range | > 172 - < 178 °C. Remarks:The atmospheric pressure at which the boiling point was measured is. |
| Flammability | Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 81 °C. Atm. press.:1 013.25 hPa. |
| Auto-ignition temperature | 369 °C. Remarks:No data on atmospheric pressure. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | dynamic viscosity (in mPa s) = 2.41. Temperature:20°C.;dynamic viscosity (in mPa s) = 2.14. Temperature:25°C. |
| Solubility | Reaction (NTP, 1992) |
| Partition coefficient n-octanol/water | log Pow = 1.12. Temperature:20 °C. Remarks:PH. |
| Vapour pressure | 1.867 hPa. Temperature:25 °C.;0.947 hPa. Temperature:20 °C. |
| Density and/or relative density | 1.219 dimensionless. Temperature:20 °C.;1.213 dimensionless. Temperature:25 °C. |
| Relative vapour density | 4.93 (EPA, 1998) (Relative to Air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
NIOSH considers dichloroethyl ether to be a potential occupational carcinogen.
The substance can form explosive peroxides on exposure to air and light. Decomposes on burning. Decomposes on contact with water. This produces toxic fumes including hydrogen chloride. Reacts with strong oxidants. Reacts violently with chlorosulfonic acid and oleum.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME, OR OXIDANTS.The vapour is heavier than air.2,2'-DICHLORODIETHYL ETHER may form phosgene or hydrogen when heated to high temperature. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154]. Mixing in equal molar portions with the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid and oleum [NFPA 1991].
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
It decomposes in presence of moisture to form hydrochloric acid.
10.6 Hazardous decomposition products
When heated to decomp, emits highly toxic fumes of /hydrogen chloride/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 75 mg/kg bw.
- Inhalation: LC50 - rat - ca. 250 ppm.
- Dermal: LD50 - rabbit - 90 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group B2 Probable Human Carcinogen
Reproductive toxicity
No information is available on the developmental or reproductive effects of dichloroethyl ether in humans. In one animal study, no effects were observed on the reproductive tissues of the animals, but no tests on reproductive function were performed.
STOT-single exposure
The substance is irritating to the eyes and respiratory tract. Inhalation of the vapour may cause lung oedema. See Notes. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Oryzias latipes - > 100 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: LC50 - Daphnia magna - 340 mg/L - 24 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 79.44 mg/L - 72 h.
- Toxicity to microorganisms: IC50 - activated sludge, domestic - > 1 000 mg/L - 3 h.
12.2 Persistence and degradability
Bis(2-chloroethyl) ether was added to Ohio River water at pH 7.2 and 22-25 deg C(1). Thirty-five days following the addition of bis(2-chloroethyl) ether to the water, 50% of the carbon dioxide theoretically derivable from bis(2-chloroethyl) ether was recovered. After a second addition of bis(2-chloroethyl) ether, only 9-10 days were required to observe 50% recovery of theoretical carbon dioxide, suggesting acclimation was necessary for optimal biodegradation rates(1). The absence of evidence of biodegradation in another study(2) may be attributed to an insufficiently long acclimation period (18 days)(SRC). Bis(2-chloroethyl) ether, present at 100 mg/l, reached 8.3% of its theoretical BOD in 3 weeks using an activated sludge inoculum(3).
12.3 Bioaccumulative potential
A BCF of 0.4 to 1.3 in carp(1) and a BCF of 11 in bluegills exposed to bis(2-chloroethyl) ether for 14 days(2) was observed. According to a classification scheme(3), these BCF values suggest that the potential for bioconcentration in aquatic organisms is low.
12.4 Mobility in soil
The Koc of bis(2- chloroethyl) ether is estimated as approximately 120(SRC), using a log Kow of 1.29(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that bis(2-chloroethyl) ether is expected to have high mobility in soil(SRC). In a 140 cm long column containing Lincoln fine sand collected in Ada, OK, 86% of the applied bis(2-chloroethyl) ether reached 140 cm, indicating minimal adsorption to this soil(4).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2810 (For reference only, please check.) | IMDG: UN2810 (For reference only, please check.) | IATA: UN2810 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.) | IMDG: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.) | IATA: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: I (For reference only, please check.) | IMDG: I (For reference only, please check.) | IATA: I (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Bis(2-chloroethyl) ether | Bis(2-chloroethyl) ether | 111-44-4 | 203-870-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation is therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert.Check for peroxides prior to distillation; eliminate if found.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
Bis(2-chloroethyl) ether is included in Organic Reagents category.
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