2,4-Diaminotoluene Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 4-methyl-m-phenylenediamine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 1,3-Benzenediamine, 4-methyl-; 2,4-TDA; tertralg |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Toluene-2,4-diamine is used primarily in the production of toluene diisocyanate, which is used in the production of polyurethane. It is used as an intermediate in the synthesis of dyes and heterocyclic compounds. Toluene-2,4-diamine is also used to prepare direct oxidation black, a dye for hair and furs, and to prepare dyes for leather. Other uses of toluene-2,4-diamine include enhancement of thermal stability in polyamides, fatigue resistance and dyeability in fibers, and the preparation of impact-resistant resins, polyimides with superior wire-coating properties, benzimidazolethiols (antioxidants), hydraulic fluids, urethane foams, fungicide stabilizers, and sensitizers for explosives. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 4, Dermal
Skin sensitization, Category 1
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Specific target organ toxicity â repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Reproductive toxicity, Category 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H301 Toxic if swallowed H312 Harmful in contact with skin H317 May cause an allergic skin reaction H341 Suspected of causing genetic defects H350 May cause cancer H373 May cause damage to organs through prolonged or repeated exposure H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment. |
| Response | P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-methyl-m-phenylenediamine | 4-methyl-m-phenylenediamine | 95-80-7 | 202-453-1 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
Rinse with plenty of water (remove contact lenses if easily possible).
Following ingestion
Rinse mouth.
4.2 Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose, throat; dermatitis; ataxia, tachycardia, nausea, vomiting, convulsions, respiratory depression; methemoglobinemia, cyanosis, headache, lassitude (weakness, exhaustion), dizziness, bluish skin; liver injury; [potential occupational carcinogen] Target Organs: Eyes, skin, respiratory system, blood, cardiovascular system, liver (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Irrigate eyes with water. Wash contaminated area of body with soap and water.
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Use water spray, foam, powder, carbon dioxide.
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic fumes are generated when heated. Behavior in Fire: Toxic gases are produced when heated to decomposition temperature. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Spillage Disposal. Personal protection: chemical protection suit including self-contained breathing apparatus. Do not let this chemical enter the environment. Do not wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Well closed. Separated from oxidants and acids. Separated from food and feedstuffs. Store in an area without drain or sewer access. Do NOT store or transport in containers made from aluminium or copper and its alloys. Provision to contain effluent from fire extinguishing.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
MAK: sensitization of skin (SH); skin absorption (H); carcinogen category: 3B
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles (if molten) or face shield.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Solid. Crystalline powder. |
|---|---|
| Colour | Pale brown. |
| Odour | no data available |
| Melting point/freezing point | 99 °C. |
| Boiling point or initial boiling point and boiling range | 288 °C. Atm. press.:Stated as atmospheric pressure. Remarks:Uncertainty of ±2°C. |
| Flammability | Combustible Solid |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 160 °C. Atm. press.:758 - 768 mm Hg. |
| Auto-ignition temperature | 505 °C. Atm. press.:750 - 765 mm Hg. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | 1 to 5 mg/mL at 70° F (NTP, 1992) |
| Partition coefficient n-octanol/water | log Pow = 0.074. Temperature:25 °C. |
| Vapour pressure | 0.017 Pa. Temperature:25 °C. Remarks:Uncertainty of ± 0.002. |
| Density and/or relative density | 1.26. Temperature:20 °C. |
| Relative vapour density | (air = 1): 4.2 |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
NIOSH considers toluenediamine to be a potential occupational carcinogen. Toluenediamine
Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides. Reacts with oxidants and acids. This generates fire and explosion hazard. Attacks copper and its alloys and aluminium.
10.2 Chemical stability
Readily becomes oxidized in neutral or alkaline soln to form dark products
10.3 Possibility of hazardous reactions
If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. Dust explosion possible if in powder or granular form, mixed with air.2,4-TOLUENEDIAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts vigorously with oxidizing agents (USCG, 1999).
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
STABILITY: This chemical is sensitive to air and moisture. It is sensitive to temperatures greater than 104 F. It is also sensitive to prolonged exposure to light. This compound readily becomes oxidized in neutral or alkaline solutions to form a dark product. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This compound may react with acids, acid chlorides, acid anhydrides, strong oxidizing agents and chloroformates. It is also incompatible with isocyanates. (NTP, 1992)
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of nitrogen oxides.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LDLo Rat oral 500 mg/kg.
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Reproductive toxicity
In humans occupationally exposed to toluene-2,4-diamine, several studies did not report any statistically significant reproductive or developmental effects. Developmental and reproductive effects were observed in animals, including a significant decrease in the number of births and increases in maternal deaths, stillbirths, and resorptions.
STOT-single exposure
The substance is mildly irritating to the eyes. The hot liquid may cause severe skin burns. The substance may cause effects on the liver and blood.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the liver and kidneys. This may result in liver function impairment and kidney impairment. This substance is possibly carcinogenic to humans. May cause genetic damage in humans. May cause reproductive toxicity in humans.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Pagrus major - 0.414 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 1.6 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 78.1 µmol/L - 96 h.
- Toxicity to microorganisms: IC50 - Vibrio fisheri - 405.7 µmol/L - 15 min.
12.2 Persistence and degradability
AEROBIC: Toluene-2,4-diamine, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A decline of 45% in the theoretical organic carbon of toluene-2,4-diamine was observed after 4 hr exposure to activated sludge in a fill and draw apparatus(2). When incubated with a synthetic batch activated sludge acclimated to the 2,4- and 2-6-isomers, diaminotoluenes, present at 300 mg/L, were 80% biodegraded in 4 days(3). Toluene-2,4-diamine, (ring-labeled), produced 35% 14-CO2 evolution in 375 days using a soil inoculum in the shake flask test(4). Adsorption to soil is expected to attenuate biodegradation(5). Using an inoculum from a munitions manufacturing wastewater treatment plant in Radford, VA, toluene-2,4-diamine, present at 500 mg/L, yielded 41.1 mg COD, with each 0.55 mM addition being consumed within 2-4 days(6).
12.3 Bioaccumulative potential
A BCF range of 1.9-3.3 was measured in fish for toluene-2,4-diamine, present at 1 mg/L, and orange-red killifish (Oryzias latipes) which were exposed over an 6-week period(1). According to a classification scheme(3), this BCF range suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using aerobic conditions with a Washington silt loam surface soil (21% sand; 60% silt; 19% clay; pH 5; 1.3% total organic carbon) from a farm field planted with a rotation of corn and soybeans near Bethehem, PA and a Freehold sandy loam soil (53% sand; 40% silt; 7% clay; pH 5.8; 1.6% total organic carbon) from the Rutgers Experimental Farm, Adelphia, NJ, the Koc of toluene-2,4-diamine were measured to be 1331 and 1346, respectively. Under anaerobic conditions, Koc values were 713 and 1054, respectively(1). According to a classification scheme(2), this estimated Koc value suggests that toluene-2,4-diamine is expected to have low mobility in soil. The estimated pKa of toluene-2,4-diamine is 5.35(3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that mobility may be much lower in some soils(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN1709 (For reference only, please check.) | IMDG: UN1709 (For reference only, please check.) | IATA: UN1709 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: 2,4-TOLUYLENEDIAMINE, SOLID (For reference only, please check.) | IMDG: 2,4-TOLUYLENEDIAMINE, SOLID (For reference only, please check.) | IATA: 2,4-TOLUYLENEDIAMINE, SOLID (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 4-methyl-m-phenylenediamine | 4-methyl-m-phenylenediamine | 95-80-7 | 202-453-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.Often transported in the molten state.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
2,4-Diaminotoluene is included in Organic Reagents category.
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