1-Chloro-3-nitrobenzene Safety Data Sheets

Acute toxicity - Category 4, Oral

Eye irritation, Category 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound may include cyanosis from methemoglobinemia; and blood changes. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

Use water spray, foam, carbon dioxide.

Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Chloronitrobenzenes, meta, solid

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from combustible substances, reducing agents and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Store in a cool, dry, well ventilated location. Separate from alkalies and oxidizing materials.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). This generates fire and explosion hazard. The substance is a strong oxidant. It reacts with combustible and reducing materials.

no data available

Dust explosion possible if in powder or granular form, mixed with air.3-CHLORONITROBENZENE can react with oxidizing materials. (NTP, 1992).

no data available

Reacts with alkalies, oxidizing materials.

no data available

Acute toxicity

• Oral: LD50 - rat - 400 mg/kg bw. Remarks:Mortalities were observed at 251, 316, 398 and 501 mg/kg.
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Pimephales promelas - 18.8 mg/L - 96 h.
• Toxicity to daphnia and other aquatic invertebrates: LC50 - Daphnia magna - 20 mg/L - 48 h.
• Toxicity to algae: EC50 - Scenedesmus pannonicus - 1.9 mg/L - 14 d.
• Toxicity to microorganisms: EC50 - Photobacterium phosphoreum - 13.1 mg/L - 15 min.

AEROBIC: 1-Chloro-3-nitrobenzene was tested for biodegradability using the OECD, river die-away, and Pitter tests; the half-life for 1-chloro-3-nitrobenzene was much greater than four weeks for these tests using both unadapted and adapted inoculum(1). A lack of significant ring cleavage by day 64, as measured by UV spectroscopy, showed that 1-chloro-3-nitrobenzene at 10 ug/mL did not degrade readily in aqueous suspensions of Niagara silt loam(2). This analytical method was not selective enough however, to determine whether biotransformations not involving aromatic ring cleavage may have taken place(2). Information from studies to determine the effectiveness of various drinking water purification methods in the Netherlands suggests that 1-chloro-3-nitrobenzene may be biodegraded in soil(3). The removal of 1-chloro-3-nitrobenzene from bank-filtered water that was observed in these studies, may have been due partly to biodegradation; however, the contribution of other processes such as adsorption was not determined. In an earlier study, 1-chloro-3-nitrobenzene was measured in bank-filtered Rhine River water retained for a time of >1 year(4). The biodegradation half-life of 1-chloro-3-nitrobenzene was >64 days in solutions using microorganisms derived from a soil inoculum(5).

Rainbow trout (Salmo gairdneri) were fed a mixture of 14 different chloronitrobenzenes, including 1-chloro-3-nitrobenzene, and the amount of 1-chloro-3-nitrobenzene present in the fish was measured over 36 days(1). 1-Chloro-3-nitrobenzene was present in trace amounts 3 days following exposure and was not detectable (<5 ug/kg fish) after 8 days. Fish in water containing 800 ng/L of 1-chloro-3-nitrobenzene plus the same mixture of chloronitrobenzenes had BCF values for 1-chloro-3-nitrobenzene of 77 after 5 days to 91 after 36 days with a mean BCF of 78(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is moderate(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-chloro-3-nitrobenzene can be estimated to be 310(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-chloro-3-nitrobenzene is expected to have moderate mobility in soil(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) BEI issued (ACGIH 2006).See ICSC 0028.Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Rinse contaminated clothing with plenty of water because of fire hazard.