4-Chlorobenzoic acid Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 4-chlorobenzoic acid |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 4 CHLOROBENZOIC ACID; 4-chloro-benzoic acid; 4-CHLOROBENZOIC ACID FOR SYNTHESIS |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research uses. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-chlorobenzoic acid | 4-chlorobenzoic acid | 74-11-3 | 200-805-9 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms resulting from exposure to this compound include eye and skin irritation. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is irritating to eyes, skin, mucous membranes and the upper respiratory tract. Decomposition produces toxic gases. (NTP, 1992)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Organic acids and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
Flash point data for this compound are not available; however, it is probably combustible. (NTP, 1992)
5.3 Special protective actions for fire-fighters
Use water spray, powder.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety spectacles.
Skin protection
Protective gloves.
Respiratory protection
Use ventilation.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | PHYSICAL DESCRIPTION: Triclinic crystals or light fluffy white powder. (NTP, 1992) |
|---|---|
| Colour | Triclinic prisms from alcohol and ether |
| Odour | no data available |
| Melting point/freezing point | 36°C(lit.) |
| Boiling point or initial boiling point and boiling range | 75°C |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 10°C(lit.) |
| Auto-ignition temperature | 545°C |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 59° F (NTP, 1992) |
| Partition coefficient n-octanol/water | 2.65 |
| Vapour pressure | 2.92X10-5 mm Hg at 25 deg C (est) |
| Density and/or relative density | 1.374 g/cm3 |
| Relative vapour density | (air = 1): 5.4 |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
On combustion, forms toxic and corrosive fumes including hydrogen chloride. The solution in water is a weak acid.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
P-CHLOROBENZOIC ACID is incompatible with strong oxidizing agents and strong bases. (NTP, 1992)
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible materials: Strong oxidizing agents, strong bases.
10.6 Hazardous decomposition products
When heated to decomposition is emits toxic vapors of chloride.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 1170 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
See Notes.
STOT-repeated exposure
See Notes.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached when dispersed.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, static; Concentration: >20000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: The biodegradation of p-chlorobenzoic acid varies considerably; biodegradation can be rapid under some conditions and slow under other conditions(SRC). p-Chlorobenzoic acid was degraded at 65 BOD% after 5 days in river water collected from the Songhua river of Jillin Province, China(1). Biodegradation of p-chlorobenzoic acid, present at 50 ug/L in activated sludge, was approximately 6% CO2 after 5 days(2). The percentage of 14-C02 recovered from river die-away tests using freshwater from Fall Creek, Ithaca, NY, and 14-C labeled p-chlorobenzoic acid following 4, 6, 8 and 12 days of aerobic incubation were 47.6%, 51.3%, 60.3%, no data at 47 pg/mL; 17.1%, 33.0%, 48.0%, no data at 4.7 ng/mL; 2.03%, 3.6%, no data, 79% at 470 ng/mL; and 1.2%, 1.4%, no data, 5.9% at 47 ug/mL(3). No degradation was found after > 25 days for p-chlorobenzoic acid present at 16 mg/L in both wastewater sludge and a soil inoculum(4). 100% decomposition (as measured by UV absorption loss) of p-chlorobenzoic acid was observed after 64 days in the soil(5).
12.3 Bioaccumulative potential
The BCF in golden ide (Leuciscus idus melanotus) fish was reported to be < 10 in a 3-day experiment(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of p-chlorobenzoic acid is estimated as 42(SRC), using a log Kow of 2.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that p-chlorobenzoic acid is expected to have very high mobility in soil. The pKa of p-chlorobenzoic acid is 3.98(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2811 (For reference only, please check.) | IMDG: UN2811 (For reference only, please check.) | IATA: UN2811 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.) | IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.) | IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: I (For reference only, please check.) | IMDG: I (For reference only, please check.) | IATA: I (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 4-chlorobenzoic acid | 4-chlorobenzoic acid | 74-11-3 | 200-805-9 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Not Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
4-Chlorobenzoic acid is included in Bulk Drug Intermediates category.
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