4-Nitro-1,2-phenylenediamine Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 4-nitro-o-phenylenediamine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 1,2-Benzenediamine, 4-nitro-; 4-nitrobenzene-1,2-diamine; 4-Nitro-o-phenylenediamine |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research uses. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin sensitization, Category 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H317 May cause an allergic skin reaction |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-nitro-o-phenylenediamine | 4-nitro-o-phenylenediamine | 99-56-9 | 202-766-3 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth.
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include irritation of the skin, eyes, mucous membranes and upper respiratory tract, and allergic skin reaction. ACUTE/CHRONIC HAZARDS: This compound is highly toxic by ingestion and inhalation. It is an irritant of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon dioxide, carbon monoxide and nitrogen oxides. (NTP, 1992)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
INHALATION: Fresh air, rest. SKIN: Remove contaminated clothes. Rinse skin with plenty of water or shower. EYES: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION: Rinse mouth
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Water spray, powder.
5.2 Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
5.3 Special protective actions for fire-fighters
Use water spray, powder.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
6.3 Methods and materials for containment and cleaning up
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from incompatible materials. See Chemical Dangers.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | PHYSICAL DESCRIPTION: Dark red needles or red solid. (NTP, 1992) |
|---|---|
| Colour | Dark red needles from dilute alcohol |
| Odour | no data available |
| Melting point/freezing point | -91°C(lit.) |
| Boiling point or initial boiling point and boiling range | 88°C(lit.) |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | -2°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 68.9° F (NTP, 1992) |
| Partition coefficient n-octanol/water | log Kow = 0.88 |
| Vapour pressure | 1.09X10-4 mm Hg at 25 deg C (est) |
| Density and/or relative density | 1.446g/cm3 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on burning. This produces toxic fumes including nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
4-NITRO-O-PHENYLENEDIAMINE is incompatible with strong oxidizing agents, strong acids, strong reducing agents, acid chlorides and acid anhydrides. (NTP, 1992)
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
The substance decomposes on burning producing toxic fumes including nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents.
10.6 Hazardous decomposition products
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral (oil-water emulsion) 3720 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Information is not available regarding the biodegradation potential of 4-nitro-1,2-diaminobenzene; however, 33% percent of structurally-related o-phenylenediamine was removed over 120 hours based on chemical oxygen demand measurements and using an activated sludge inoculum(1).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for 4-nitro-1,2-diaminobenzene(SRC), using a log Kow of 0.88(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of 4-nitro-1,2-diaminobenzene is estimated as 72(SRC), using a log Kow of 0.88(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 4-nitro-1,2-diaminobenzene is expected to have high mobility in soil. However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4), suggesting that mobility may be much lower in some soils(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 4-nitro-o-phenylenediamine | 4-nitro-o-phenylenediamine | 99-56-9 | 202-766-3 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The substance is combustible but no flash point is available in literature.Do NOT take working clothes home.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
4-Nitro-1,2-phenylenediamine is included in Hair Dyeing category.
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