4-Aminobiphenyl Safety Data Sheets

Acute toxicity - Category 4, Oral

Carcinogenicity, Category 1A

If inhaled

Following skin contact

Following eye contact

Following ingestion

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Headache, dizziness; drowsiness, dyspnea (breathing difficulty); ataxia, lassitude (weakness, exhaustion); methemoglobinemia; urinary burning; acute hemorrhagic cystitis; [potential occupational carcinogen] Target Organs: Bladder, skin (NIOSH, 2016)

This chemical is probably combustible. (NTP, 1992)

Use water spray, dry powder, foam, carbon dioxide.

Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants and acids. Well closed.Keep container tightly closed in a dry and well-ventilated place.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

On combustion, forms toxic gases. Reacts with strong oxidants and acids.

Stable under recommended storage conditions.

Slight to moderate when exposed to heat, flames, (sparks) or powerful oxidizers.4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. (NTP, 1992). May react with strong oxidizing agents.

no data available

Incompatible materials: Strong oxidizing agents.

Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx).

Acute toxicity

• Oral: LD50 Rat oral 500 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: no data available
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: 4-Biphenylamine was 0-50% degraded at the end of a 28 day test period in a static biodegradability test in which 2 mg/L of the compound was seeded with sludge, mineral salts, 5 mg/l yeast, with 7-day static incubation followed by 3 weekly subcultures(1); this was considered as slowly degraded with acclimation under the conditions of this test system(1). In another static system procedure where a 1% solution of the chemical in an emulsifier was added to a bacterial suspension at a concentrations of 1 to 2 ppm, 4-biphenylamine was 50% degraded at the end an initial 7-day incubation period(2). Two analogous compounds, aniline (phenylamine) and biphenyl, were classified as readily biodegradable by the Japanese MITI test (OECD Guideline 301C)(3). Aniline and biphenyl, present at 100 mg/L, reached 85 and 66% of their respective theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3).

An estimated BCF of 36 was calculated in fish for 4-biphenylamine(SRC), using a log Kow of 2.86(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 4-biphenylamine can be estimated to be 2470(SRC). According to a classification scheme(2), this estimated Koc value suggests that 4-biphenylamine is expected to have slight mobility in soil. Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be lower in some soils(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.Special attention should be given to urine sediment and cytology.Special attention should be given to blood in urine.Do NOT take working clothes home.