Bis(2-chloro-1-methylethyl) ether Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Bis(2-chloro-1-methylethyl) ether |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Bis(2-chloroisopropyl) Ether; 2-Chloroisopropyl ether; 2,2â-oxybis(1-chloropropane) |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research uses. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 2, Oral
Skin irritation, Category 2
Eye irritation, Category 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H300 Fatal if swallowed H315 Causes skin irritation H319 Causes serious eye irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
| Response | P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Bis(2-chloro-1-methylethyl) ether | Bis(2-chloro-1-methylethyl) ether | 108-60-1 | 203-598-3 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Give one or two glasses of water to drink.
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include toxic effects to the liver and kidneys. It may cause skin and respiratory tract irritation. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the eyes and respiratory tract. It may be absorbed through the skin. It is a corrosive material. When heated to decomposition it emits highly toxic fumes of chlorine. (NTP, 1992)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Treat frostbite by rapid rewarming . Ethers and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Water to blanket fire, foam, carbon dioxide, dry chemical.
5.2 Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
5.3 Special protective actions for fire-fighters
Use water spray, foam, alcohol-resistant foam, dry powder, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable plastic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable plastic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Waste water treatment: Activated carbon: absorbability: 0.20 g/g C; 100% redn, at 1,800 mg/l influent; conventional municipal; treatment: influent 0.024 mg/l; conventional plus activated carbon: influent 0.048 mg/l.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Above 85°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Cool. Keep in the dark. Separated from incompatible materials. See Chemical Dangers.Ethers should not be stored near powerful oxidizers or in areas of high fire hazard. They should be kept cool and the containers electrically grounded to avoid sparks. Ethers
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety spectacles.
Skin protection
Protective gloves.
Respiratory protection
Use local exhaust.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | PHYSICAL DESCRIPTION: Colorless to light brown liquid. Odor threshold concentration 200 µg/L. (NTP, 1992) |
|---|---|
| Colour | Colorless liquid |
| Odour | no data available |
| Melting point/freezing point | -97 to -102ºC |
| Boiling point or initial boiling point and boiling range | 187ºC at 760 mmHg |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 36.4ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 0.0230 POISE @ 20 DEG C |
| Solubility | less than 0.1 mg/mL at 72° F (NTP, 1992) |
| Partition coefficient n-octanol/water | log Kow= 2.48 |
| Vapour pressure | 0.887mmHg at 25°C |
| Density and/or relative density | 1.086 g/cm3 |
| Relative vapour density | 6 (NTP, 1992) (Relative to Air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
The substance can form explosive peroxides on standing in contact with air. Reacts with halogens, strong acids and strong oxidants. Decomposes on burning. This produces toxic fumes.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
MODERATE, WHEN EXPOSED TO HEAT, FLAME OR POWERFUL OXIDIZERS.BIS(2-CHLORO-1-METHYLETHYL)ETHER oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164].
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible with oxidizing materials
10.6 Hazardous decomposition products
When heated to decomp, emits highly toxic fumes of /hydrogen chloride/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat single oral 0.24 (0.22-0.27 g/kg in a suitable vehicle). From table
- Inhalation: LC50 Rat inhalation 350 ppm/8 hr
- Dermal: LD50 Rabbit single percutaneous 3.00 (1.78-5.04) ml/kg. From table
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of bis(2-chloro-1-methylethyl)ether were available. There is limited evidence in experimental animals for the carcinogenicity of bis(2-chloro-1-methylethyl)ether. Overall evaluation: Bis(2-chloro-1-methylethyl)ether is not classifiable as to its carcinogenicity to humans (Group 3).
Reproductive toxicity
no data available
STOT-single exposure
See Notes.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC GRAB SAMPLES: Bis(2-chloro-1-methylethyl) ether showed no biodegradation after 5 days at 20 deg C when incubated with Ohio River water at an initial concentration of 33 mg/l(1). Three bank infiltration studies from the Rhine river in The Hague showed a concentration of approximately 0.5 ug/l, which was not reduced at all after infiltration(2). In the Netherlands, 33% removal in <1 yr and 90% removal in <3 months was observed after bank and dune infiltration of Rhine water, respectively(3). A degradation half-life has been estimated to be 59 days and 3.1 days for bis(2-chloro-1-methylethyl) ether in a lake in the Rhine basin and in the Rhine river, respectively, based upon field monitoring data (includes dilution and evaporation)(3). AEROBIC SCREENING STUDIES: Bis(2-chloro-1-methylethyl) ether, present at 100 mg/l, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum(4). Bis(2-chloro-1-methylethyl) ether did not degrade after an experimental period of 40 days under aerobic conditions(5). In a static-culture-flask biodegradation screening procedure, utilizing biochemical oxygen demand and dilution water containing 5 mg of yeast extract per liter as the synthetic medium, bis(2-chloro-1-methylethyl) ether was found to be significantly biodegradable with rapid adaptation. At a test concentration of 5 mg/l, the original culture achieved 85% biodegradation in 7 days and subcultures 100% in 7 days; when the test concentration was 10 mg/l, 63% biodegradation of the original culture was observed in 7 days and 100% in subcultures(6).
12.3 Bioaccumulative potential
The weighted average bioconcentration factor for ... bis(2-chloroisopropyl) ether /in/ the edible portion of all freshwater and estuarine aquatic organisms consumed by Americans is calculated to be ... 2.47.
12.4 Mobility in soil
Because of its water solubility, some migration through the soil may occur.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2490 (For reference only, please check.) | IMDG: UN2490 (For reference only, please check.) | IATA: UN2490 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: DICHLOROISOPROPYL ETHER (For reference only, please check.) | IMDG: DICHLOROISOPROPYL ETHER (For reference only, please check.) | IATA: DICHLOROISOPROPYL ETHER (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Bis(2-chloro-1-methylethyl) ether | Bis(2-chloro-1-methylethyl) ether | 108-60-1 | 203-598-3 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
Bis(2-chloro-1-methylethyl) ether is included in Standard category.
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