o-Tolidine Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 4,4'-bi-o-toluidine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 3,3'-Dimethylbenzidine 4,4'-Bianisidine; Ellms-Hauser; 4,4'-Diamino-3,3'-dimethylbiphenyl |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | 3,3'-Dimethylbenzidine is used as an intermediate for the production of dyes and pigments. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H302 Harmful if swallowed H350 May cause cancer H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment. |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4,4'-bi-o-toluidine | 4,4'-bi-o-toluidine | 119-93-7 | 204-358-0 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
Rinse with plenty of water (remove contact lenses if easily possible).
Following ingestion
Rinse mouth. Give one or two glasses of water to drink.
4.2 Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, nose Target Organs: Eyes, respiratory system, liver, kidneys (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aniline and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Use powder, water spray, foam, carbon dioxide.
5.2 Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
5.3 Special protective actions for fire-fighters
Use powder, water spray, foam, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
A new method developed for the removal of carcinogenic aromatic amines from industrial aqueous effluents uses horseradish peroxidase & hydrogen peroxide resulting in a nearly complete precipitation of carcinogenic aromatic amines from water due to enzymatic crosslinking.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: carcinogen category: 2
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety spectacles.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use closed system or ventilation.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | PHYSICAL DESCRIPTION: White to reddish crystals or crystalline powder or a light tan powder. (NTP, 1992) |
|---|---|
| Colour | Colorless; in technical grades also brownish flakes |
| Odour | no data available |
| Melting point/freezing point | 131 ~ 132 °C |
| Boiling point or initial boiling point and boiling range | 300 °C |
| Flammability | Combustible Solid |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 244 °C |
| Auto-ignition temperature | 526°C |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Miscible with water |
| Partition coefficient n-octanol/water | log Kow = 2.34 |
| Vapour pressure | 2.14E-05mmHg at 25°C |
| Density and/or relative density | 1.2 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
NIOSH considers o-tolidine to be a potential occupational carcinogen.
Decomposes on burning. This produces toxic fumes including nitrogen oxides. Reacts with oxidants.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
3,3'-DIMETHYLBENZIDINE is sensitive to exposure to light. May be sensitive to prolonged exposure to air. A weak base that forms salts with hydrochloric acid or sulfuric acid. It can be acetylated. Incompatible with strong agents (NTP, 1992).
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizers.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
This substance/agent has not undergone a complete evaluation under U.S. EPA's IRIS program for evidence of human carcinogenic potential.
Reproductive toxicity
No information is available on the reproductive or developmental effects of 3,3'-dimethylbenzidine in humans or animals. Immature sperm forms were observed in the testis and epididymus of male rats exposed to 3,3'-dimethylbenzidine dihydrochloride in drinking water.
STOT-single exposure
no data available
STOT-repeated exposure
This substance is probably carcinogenic to humans.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly , especially if powdered.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, renewal, 25 deg C, pH >7; Concentration: 3200 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: In a Warburg respirometer that used activated sludge from both domestic and industrial discharges, 100% of the 3,3'-dimethylbenzidine (initial concentration 20 mg/L) was depleted in 6 hours at 25 deg C(1). 3,3'-Dimethylbenzidine, present at 100 mg/L, reached 3% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(2,3), indicating the compound is not readily biodegradable(3).
12.3 Bioaccumulative potential
Using carp (Cyprinus carpio) which were exposed over an 8-week period in a continuous flow system and 3,3'-dimethylbenzidine concentrations of 0.02 and 0.2 mg/L, a 3,3'-dimethylbenzidine BCF range of 4.8 to 83 was measured(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low to moderate(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of 3,3'-dimethylbenzidine can be estimated to be 3190(SRC). According to a classification scheme(2), this estimated Koc value suggests that 3,3'-dimethylbenzidine is expected to have slight mobility in soil. The pKa value of 3,3'-dimethylbenzidine are 4.50 and 3.3(3), indicating that this compound will exist partially in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). In sorption studies using colloidal sediment collected from the Chesapeake Bay estuary, 3,3'-dimethylbenzidine had a colloid Koc value (Kcoll) of 2014(5); sorption measurements over the pH range of 5 to 9 saw a significant increase in sorption as the pH decreased suggesting that the protonated form of 3,3'-dimethylbenzidine was more strongly bound than the neutral form(5).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN3077 (For reference only, please check.) | IMDG: UN3077 (For reference only, please check.) | IATA: UN3077 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.) | IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.) | IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 9 (For reference only, please check.) | IMDG: 9 (For reference only, please check.) | IATA: 9 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 4,4'-bi-o-toluidine | 4,4'-bi-o-toluidine | 119-93-7 | 204-358-0 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
o-Tolidine is included in Organic Reagents category.
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