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    Home > SDS > Hexadecyltrimethylammonium chloride


    According to the UN GHS revision 8

    Version: 1.0

    Creation Date: July 15, 2019

    Revision Date: July 15, 2019

    1. Identification

    1.1 GHS Product identifier

    Product name

    Cetrimonium chloride

    1.2 Other means of identification

    Product number


    Other names

    Hexadecyltrimethylammonium chloride;Cetyltrimethylammonium Chloride;Hexadecyltrimethylammonium Chloride

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses

    Adhesives and sealant chemicals,Intermediates,Surface active agents

    Uses advised against

    no data available

    1.4 Supplier's details





    1.5 Emergency phone number

    Emergency phone number

    Service hours

    Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2. Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 4

    Acute toxicity - Dermal, Category 3

    Skin corrosion, Category 1C

    Serious eye damage, Category 1

    Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    2.2 GHS label elements, including precautionary statements

    Signal word


    Hazard statement(s)

    H302 Harmful if swallowed

    H311 Toxic in contact with skin

    H314 Causes severe skin burns and eye damage

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.


    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P321 Specific treatment (see ... on this label).

    P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

    P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P363 Wash contaminated clothing before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P310 Immediately call a POISON CENTER/doctor/…

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P391 Collect spillage.


    P405 Store locked up.


    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    2.3 Other hazards which do not result in classification

    no data available

    3. Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    Cetrimonium chloride Cetrimonium chloride 112-02-7 203-928-6 100%

    4. First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Medical attention is required. Consult a doctor. Show this safety data sheet (SDS) to the doctor in attendance.

    If inhaled

    Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

    Following skin contact

    Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

    Following eye contact

    Rinse with pure water for at least 15 minutes. Consult a doctor.

    Following ingestion

    Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

    4.2 Most important symptoms/effects, acute and delayed

    Ingestion may produce toxic effects. Contact with eyes or skin may cause severe damage. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    no data available

    5. Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Dry chem, /alcohol/ foam, or carbon dioxide. water may be ineffective on fire. cool exposed containers with water. cetyltrimethylammonium chloride soln

    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Irritating fumes of hydrogen chloride may form in fires. Behavior in Fire: Solvent vapors are heavier than air and may travel to a source of ignition and flash back. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6. Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

    6.2 Environmental precautions

    Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

    6.3 Methods and materials for containment and cleaning up

    Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

    7. Handling and storage

    7.1 Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    7.2 Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

    8. Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    8.2 Appropriate engineering controls

    Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

    Skin protection

    Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

    Thermal hazards

    no data available

    9. Physical and chemical properties

    Physical state

    Solid. Powder.




    no data available

    Melting point/ freezing point

    99 °C. Remarks:Melting temperature range: 90 to 99ºC.

    Boiling point or initial boiling point and boiling range

    248 °C. Remarks:Boiling temperature range was 235 to 248ºC.


    no data available

    Lower and upper explosion limit / flammability limit


    Flash point

    69° F (USCG, 1999)

    Auto-ignition temperature

    750° F (USCG, 1999)

    Decomposition temperature

    no data available


    no data available

    Kinematic viscosity

    no data available


    Water solubility: 440 mg/l at 30 deg C

    Partition coefficient n-octanol/water

    Pow = 1 208.3. Temperature:25 °C.;log Pow = 3.08. Temperature:25 °C.

    Vapour pressure

    < 0.002 Pa. Temperature:20 °C. Remarks:(i.e., equivalent to.;< 0.006 Pa. Temperature:25 °C. Remarks:(i.e., equivalent to.

    Density and/or relative density

    0.96 g/cm³. Temperature:20 °C.;960. Temperature:20 °C.

    Relative vapour density

    no data available

    Particle characteristics

    no data available

    10. Stability and reactivity

    10.1 Reactivity

    No rapid reaction with air. No rapid reaction with water.

    10.2 Chemical stability

    no data available

    10.3 Possibility of hazardous reactions

    HEXADECYLTRIMETHYLAMMONIUM CHLORIDE is a quaternary ammonium compound. Therefore it has a permanently charged nitrogen atom with four alkyl or aryl groups on it. Compounds in this group are generally soluble in water and are near pH 7 (neutral). They do not undergo the acid-base reactions typical of primary, secondary, or tertiary ammonium ions. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics.

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    no data available

    10.6 Hazardous decomposition products

    When heated to decomposition it emits very toxic fumes of /hydrogen chloride and nitrogen oxides/.

    11. Toxicological information

    Acute toxicity

    • Oral: LD50 - rat (male/female) - ca. 699 mg/kg bw.
    • Inhalation: no data available
    • Dermal: LD50 - rabbit (male) - 1 300 mg/kg bw.

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available


    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12. Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - 0.59 mg/L - 96 h. Remarks:(no information on % ai).
    • Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 280 µg/L - 48 h.
    • Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 0.11 mg/L - 96 h.
    • Toxicity to microorganisms: EC10 - Pseudomonas putida - 0.4 mg/L - 16 h. Remarks:(based on ca. 30% a.i. in test substance).

    12.2 Persistence and degradability

    The cationic surfactants biodegradation in sewage and river water was studied, measuring the reduction of the active substance by a colorimetric method using sodium alizarine sulfonate.

    12.3 Bioaccumulative potential

    An estimated BCF of 71 was calculated for trimethylhexadecylammonium chloride(SRC), using an estimated log Kow of 3.23(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

    12.4 Mobility in soil

    Using a structure estimation method based on molecular connectivity indices(1), the Koc for trimethylhexadecylammonium chloride can be estimated to be 2.2X10+5(SRC). According to a classification scheme(2), this estimated Koc value suggests that trimethylhexadecylammonium chloride is expected to immobile in soil.

    12.5 Other adverse effects

    no data available

    13. Disposal considerations

    13.1 Disposal methods


    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14. Transport information

    14.1 UN Number

    ADR/RID: no data available IMDG: no data available IATA: no data available

    14.2 UN Proper Shipping Name

    ADR/RID: no data available IMDG: no data available IATA: no data available

    14.3 Transport hazard class(es)

    ADR/RID: 6.1 (For reference only, please check.) IMDG: 6.1 (For reference only, please check.) IATA: 6.1 (For reference only, please check.)

    14.4 Packing group, if applicable

    ADR/RID: III (For reference only, please check.) IMDG: III (For reference only, please check.) IATA: III (For reference only, please check.)

    14.5 Environmental hazards


    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15. Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Cetrimonium chloride Cetrimonium chloride 112-02-7 203-928-6
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Not Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.
    Korea Existing Chemicals List (KECL) Listed.

    16. Other information

    Information on revision

    Creation Date July 15, 2019
    Revision Date July 15, 2019

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%


    • IPCS - The International Chemical Safety Cards (ICSC), website:
    • HSDB - Hazardous Substances Data Bank, website:
    • IARC - International Agency for Research on Cancer, website:
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
    • CAMEO Chemicals, website:
    • ChemIDplus, website:
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
    • Germany GESTIS-database on hazard substance, website:
    • ECHA - European Chemicals Agency, website:
    Any questions regarding this SDS, Please send your inquiry to

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

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