Hexazinone Safety Data Sheets

Acute toxicity - Category 4, Oral

Eye irritation, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

no data available

no data available

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Stable under normal storage conditions for at least 2 years.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Water soluble. Rapidly decomposed in solution by strong acids and bases.

Stable in aqueous media between pH 5 and pH 9 and below 37 deg C. ...Stable to light.

A triazine.

no data available

no data available

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

Acute toxicity

• Oral: LD50 Rat oral 1690 mg/kg
• Inhalation: LC50 Rat inhalation >7.48 mg/L/1 hr exposure
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 Lepomis macrochirus (bluegill) >100 mg/L/96 hr. Static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/L.
• Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; intoxication, immobilization) 33.1 ppm/21 days (95% confidence interval: 28.1-36.9 ppm); renewal
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: Greenhouse soil degradation studies in both silt loam and sandy loam soil showed a half-life for primary degradation of <4 mo(1). Laboratory studies using C-14 labeled hexazinone with these soils showed that after an initial lag period of 10-20 days, the rate of CO2 evolution increased rapidly with 45-75% of the applied radioactivity being evolved as CO2 during the 80 day incubation period(1). The degradation of hexazinone in Taloka and Mountainberg soils incubated in the dark at 30 deg C and 10 deg C followed first order kinetics(2). The respective half-lives were 77 and 76 days at 30 deg C and 502 and 426 days at 10 deg C(2). In contrast, when incubated in stream water, no significant degradation occurred at 10 deg C; the hexazinone concn decreased about 2.2% in 200 days at 30 deg C, indicating a half-life of many years(2).

The BCF in bluegill sunfish exposed to 0.01 and 1.0 ppm C14-radiolabeled hexazinone for 4 weeks was 2 and 1, respectively. Residue levels plateaued after 1-2 weeks of exposure. Maximum BCF were 2, 3-5, and 5-7 in the carcass, liver, and viscera, respectively(1). The hexazinone levels in the fish declined by over 90% after a 1 week depuration period and no residues were detected after 2 weeks(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

A soil column leaching study used (14)C-hexazinone, half of which was aged for 30 days and applied to Flanagan silt loam and Fallsington sandy loam. Leaching with a total of 20 inches of water showed unaged hexazinone leached in the soils; however, leaching rates were slower for the aged samples, indicating that the degradation products may have less potential for contaminating ground water.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/