m-Toluidine Safety Data Sheets

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

Absorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation. (USCG, 1999)

Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire. (USCG, 1999)

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

NO open flames. Above 85°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Ventilation along the floor. Keep in the dark. Store in an area without drain or sewer access./Store/ separated from strong oxidants, strong acids, food and feedstuffs. Cool. Dry. Well closed. Ventilation along the floor.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. Reacts with strong oxidants and strong acids. Attacks some forms of plastic.

no data available

Flammable when exposed to heat or flame.As a result of flow, agitation, etc., electrostatic charges can be generated.M-TOLUIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].

no data available

Can react vigorously on contact with oxidizing materials.

When heated to decomposition it emits highly toxic fumes of /nitroxides/.

Acute toxicity

• Oral: LD50 - rat (male) - 922 mg/kg bw. Remarks:Clinical signs included lacrimation, stained face, chromodacryorrhea, stained and wet perineal area, cyanosis, moribundity and moderate weight loss.
• Inhalation: no data available
• Dermal: LD50 - rat (female) - 1 030 mg/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Poecilia reticulata - 36.3 mg/L - 14 d.
• Toxicity to daphnia and other aquatic invertebrates: LC50 - Daphnia magna - 0.73 mg/L - 48 h.
• Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 17.7 mg/L - 72 h.
• Toxicity to microorganisms: EC50 - other bacteria: activated sludge (from 3 L laboratory plant, OECD) - 1 572 mg/L - 3 h. Remarks:Respiration rate.

AEROBIC: 3-Aminotoluene, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In other screening tests, 3-aminotoluene was found to be readily biodegradable(2-4). In one test, 74% of theoretical BOD was achieved in 7.5 days with an activated sludge inoculum acclimated to aniline(2). In another, 97.7% degradation occurred in 5 days with an activated sludge inoculum(3). Complete degradation of 3-aminotoluene was obtained within 8 days with a soil inoculum(4). The half-life of 3-aminotoluene in natural water from ponds and rivers in which the microbial populations were increased 10- to 100-fold by filtration and nutrient addition was 4 hours(5). 3-Aminotoluene, present at 2 mg/L, reached 50% of its theoretical BOD in 5 days using water from the Songhua River in China as an inoculum(6).

An estimated BCF of 3.9 was calculated for 3-aminotoluene(SRC), using a log Kow of 1.40(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The mean Koc of 3-aminotoluene in 4 silt loam soils was 44 over a pH range of 6.1 to 7.5(1). According to a classification scheme(2), this Koc value suggests that 3-aminotoluene is expected to have very high mobility in soil. The pKa of 3-aminotoluene is 4.69(3), indicating that this compound will partially exist in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that mobility of the neutral species may be much lower in some soils(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.The odour warning when the exposure limit value is exceeded is insufficient.Do NOT take working clothes home.See ICSCs 0341 and 0343.