2-Nitroaniline Safety Data Sheets

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

If inhaled

Following skin contact

Following eye contact

Following ingestion

Inhalation or ingestion causes headache, nausea, methemo- globinemia, vomiting, weakness, and stupor; cyanosis caused by contact usually develops in 4-6 hrs.; prolonged and excessive exposure may also cause liver damage. Contact with eyes or skin causes irritation; continued exposure may cause same symptoms as inhalation or ingestion. (USCG, 1999)

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder.

1. Ventilate area of spill. 2. For small quantities, sweep onto paper or other suitable material, place in an appropriate container & burn in a safe place (such as a fume hood). Large quantities may be reclaimed; however, if this is not practical, dissolve in a flammable solvent (such as alcohol) & atomize in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

NO open flames. NO contact with combustible substances. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong acids, strong oxidants, combustible substances, reducing agents and food and feedstuffs.Protect against physical damage to containers and prevent from moisture contacts.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

On combustion, forms toxic fumes of nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents. Reacts with organic materials in the presence of moisture. This generates fire hazard.

no data available

SLIGHT, WHEN EXPOSED TO HEAT OR FLAME.Dust explosion possible if in powder or granular form, mixed with air.O-NITROANILINE may be sensitive to prolonged exposure to light. Mixtures of this chemical with magnesium are hypergolic on contact with nitric acid. It forms extremely explosive addition compounds with hexanitroethane. It has a vigorous reaction with sulfuric acid above 392° F. It is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizers. (NTP, 1992)

no data available

Forms extremely explosive addition compounds with hexanitroethane. Vigorous reaction with sulfuric acid above 200 deg C.

When heated to decomp it emits toxic fumes of /nitrogen oxides/.

Acute toxicity

• Oral: LD50 - rat (female) - 1 838 mg/kg bw.
• Inhalation: LC50 - rat (male/female) - > 2.529 mg/L air (analytical).
• Dermal: LD50 - rabbit (female) - > 20 000 mg/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Oryzias latipes - 17 mg/L - 48 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 10.1 mg/L - 48 h.
• Toxicity to algae: EC50 - Scenedesmus obliquus - 64.6 mg/L - 96 h.
• Toxicity to microorganisms: no data available

AEROBIC: In a 2 week closed bottle biodegradation test, using 100 mg/L substrate and 30 mg/L sludge, 2-nitroaniline had a theoretical BOD of 0%(1). Degradation in a soil mineral salts suspension took greater than 64 days as determined by 100% loss of UV absorbance(2). A 16% BOD threshold was measured with a Warburg respirometer using aniline-acclimated activated sludge(3). A 0% removal (based on chemical oxygen demand) was measured in a batch system using activated sludge and a 5-day incubation period(4). Biological degradation in an electrolytic respirometer using activated sludge was in excess of 10 days(5). 2-Nitroaniline was not biodegradable in an electrolytic respirometer study, although 4-nitroaniline was found to be biodegradable using the same test conditions(6). Aerobic incubation of 2-nitroaniline in a rotary shaker using sewage inocula for 52 days resulted in a maximum loss of 15% as measured by UV absorbance loss(7). A 20-day study using uniformly ring-labeled 2-nitroaniline had a 14-carbon dioxide evolution of 1.9%, measured from laboratory flask system containing a silt loam soil media(8); 14-carbon dioxide evolution was less than 0.3% from the same soil system which had been sterilized with sodium azide(8). 2-Nitroaniline had a biodegradation rate of 0.023/hr in river water giving a half-life of 31 hours, which was classified as poor degradation(9). A 5 day BOD at 20 deg C in Songhua river water was -5% for 2-nitroaniline(10).

A 6 week bioconcentration study obtained BCF values of 2.1-4.9 and <10 for concentrations of 2- nitroaniline of 0.5 and 0.05 mg/L, respectively(1). An aquarium study using carp fish found 2-nitroaniline to have a low bioaccumulation potential(2). A study using zebrafish experimentally determined the BCF for 2-nitroaniline to be 8.1(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).

The log Koc of 2-nitroaniline was measured as 1.77 giving a Koc of 59(1). According to a classification scheme(2), this Koc value suggests that 2-nitroaniline is expected to have high mobility in soil. 2-Nitroaniline was found to have a Kd value of 8.4 L/kg in homoionic K+ Montmorillonite type soil(3). However, anilines are expected to bind strongly to humus or organic matter in soils due to high reactivity of the aromatic amine group(4,5), suggesting that mobility may be much lower in some soils(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Depending on the degree of exposure, periodic medical examination is indicated.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.See ICSCs 0307 and 0308.