Pyrrolidine Safety Data Sheets

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SAFETY DATA SHEETS

According to the UN GHS revision 8

Version: 1.0

Creation Date: July 15, 2019

Revision Date: July 15, 2019

SECTION 1: Identification

1.1 GHS Product identifier

Product name	Pyrrolidine

1.2 Other means of identification

Product number	-
Other names	Tetrahydro pyrrole; Tetrahydropyrrole,Tetramethyleneimine; Pyrrolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	Food additives -> Flavoring Agents
Uses advised against	no data available

1.4 Supplier's details

Company	Echemi.com
Address	Echemi.com
Telephone	Echemi.com

1.5 Emergency phone number

Emergency phone number	Echemi.com
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

SECTION 2: Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Acute toxicity - Category 4, Oral

Skin corrosion, Sub-category 1A

Serious eye damage, Category 1

Acute toxicity - Category 4, Inhalation

2.2 GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H302 Harmful if swallowed H314 Causes severe skin burns and eye damage H332 Harmful if inhaled
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

2.3 Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1 Substances

Chemical name	Common names and synonyms	CAS number	EC number	Concentration
Pyrrolidine	Pyrrolidine	123-75-1	204-648-7	100%

SECTION 4: First-aid measures

4.1 Description of necessary first-aid measures

If inhaled

Fresh air, rest. Refer for medical attention.

Following skin contact

Rinse skin with plenty of water or shower. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Cover skin burns with dry sterile dressings after decontamination . /Organic bases/Amines and related compounds/

SECTION 5: Fire-fighting measures

5.1 Suitable extinguishing media

Alcohol foam, carbon dioxide, dry chemical

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Use foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

6.2 Environmental precautions

Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

6.3 Methods and materials for containment and cleaning up

Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: chemical protection suit including self-contained breathing apparatus.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants and acids. Well closed.Bundling and sills should be provided to prevent spread of liquid accidentally escaping from storage and process vessels.

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

MAK skin absorption (H)

Biological limit values

no data available

8.2 Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear face shield or eye protection in combination with breathing protection.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use ventilation, local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state	Liquid.
Colour	Almost colourless.
Odour	Unpleasant, ammoniacal odor
Melting point/freezing point	-57.79 Â°C.
Boiling point or initial boiling point and boiling range	86.56 Â°C. Atm. press.:1 013 hPa.
Flammability	Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit/flammability limit	LOWER: 2.9% @ -2 DEG C, UPPER 13.0% @ 29.8 DEG C
Flash point	37 Â°F.
Auto-ignition temperature	370 Â°C. Atm. press.:1 007.7 - 1 019.3 hPa. Remarks:The lowest temperature at which ignition occurred was 373Â°C. This temperature was rounded off to the nearest multiple of 5Â°C giving the auto-ignition temperature of the substance.
Decomposition temperature	no data available
pH	no data available
Kinematic viscosity	dynamic viscosity (in mPa s) = 6.147. Remarks:Temperature not known.
Solubility	Miscible with water
Partition coefficient n-octanol/water	log Pow = 0.22. Temperature:25 Â°C.
Vapour pressure	62.7 mm Hg. Temperature:25 Â°C. Remarks:This value corresponds to 8.36 kPa.
Density and/or relative density	0.85. Temperature:22.5 Â°C.
Relative vapour density	2.45 (vs air)
Particle characteristics	no data available

SECTION 10: Stability and reactivity

10.1 Reactivity

Decomposes on burning. This produces toxic fumes including nitrogen oxides. The substance is a strong base. Reacts violently with oxidants. It reacts violently with acid and is corrosive.

10.2 Chemical stability

Fumes in air

10.3 Possibility of hazardous reactions

Dangerous fire hazard when exposed to heat or flame.The vapour is heavier than air and may travel along the ground; distant ignition possible.PYRROLIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of pyrrolidine, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Can react vigorously with oxidizing materials.

10.6 Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.

SECTION 11: Toxicological information

Acute toxicity

Oral: LD50 - rat (male/female) - 430 mg/kg bw. Remarks:The original value 0.5 mL/kg was converted to mg/kg body weight using the density of 0.859 g/cmÂ³.
Inhalation: LC50 - rat (male/female) - 11.7 mg/L air (analytical).
Dermal: LD50 - rabbit (male/female) - > 0.35 - < 0.7 mL/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

The substance is corrosive to the eyes and skin. The substance is irritating to the respiratory tract. The substance may cause effects on the nervous system.

STOT-repeated exposure

no data available

Aspiration hazard

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20Â°C.

SECTION 12: Ecological information

12.1 Toxicity

Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - 115 mg/L - 96 h.
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 63 mg/L - 48 h.
Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 39 mg/L - 72 h.
Toxicity to microorganisms: EC50 - activated sludge, domestic - > 1 000 mg/L - 30 min. Remarks:Respiration rate.

12.2 Persistence and degradability

AEROBIC: Flasks, containing 20 mL of basal salts inoculated with 1 mL of fresh sewage sludge, were incubated aerobically with agitation at 28 deg C. After one week, these enrichment cultures were assayed for cell protein yield by the Lowry method. Pyrrolidine degradation displayed an increase of protein yield of 170 ug/mL from a maximum protein yield potential of 175 ug/mL, suggesting biodegradability(1).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for pyrrolidine(SRC), using a log Kow of 0.46(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of pyrrolidine is estimated as 42(SRC), using a log Kow of 0.46(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that pyrrolidine is expected to have very high mobility in soil. The pKa of pyrrolidine is 11.31(4), indicating that this compound will primarily exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

SECTION 13: Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

14.1 UN Number

ADR/RID: UN1922 (For reference only, please check.)

IMDG: UN1922 (For reference only, please check.)

IATA: UN1922 (For reference only, please check.)

14.2 UN Proper Shipping Name

ADR/RID: PYRROLIDINE (For reference only, please check.)

IMDG: PYRROLIDINE (For reference only, please check.)

IATA: PYRROLIDINE (For reference only, please check.)

14.3 Transport hazard class(es)

ADR/RID: 3 (For reference only, please check.)

IMDG: 3 (For reference only, please check.)

IATA: 3 (For reference only, please check.)

14.4 Packing group, if applicable

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

14.5 Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name	Common names and synonyms	CAS number	EC number
Pyrrolidine	Pyrrolidine	123-75-1	204-648-7
European Inventory of Existing Commercial Chemical Substances (EINECS)			Listed.
EC Inventory			Listed.
United States Toxic Substances Control Act (TSCA) Inventory			Listed.
China Catalog of Hazardous chemicals 2015			Listed.
New Zealand Inventory of Chemicals (NZIoC)			Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)			Listed.
Vietnam National Chemical Inventory			Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Listed.
Korea Existing Chemicals List (KECL)			Not Listed.

SECTION 16: Other information

Information on revision

Creation Date	July 15, 2019
Revision Date	July 15, 2019

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Pyrrolidine is included in Synthetic Fragrances category.