1H-1,2,4-Triazol-5-amine Safety Data Sheets

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

Reproductive toxicity, Category 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin; dyspnea (breathing difficulty), muscle spasms, ataxia, anorexia, salivation, increased body temperature; lassitude (weakness, exhaustion), skin dryness, depression (thyroid function suppression) Target Organs: Eyes, skin, thyroid (NIOSH, 2016)

Literature sources indicate that this compound is non-combustible. (NTP, 1992)

Use water spray, foam, powder, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal . The plastic bag should be sealed immediately . The sealed bag should be labelled properly . Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bags, so that outer surface ... is not contaminated . The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store in an area without drain or sewer access. Separated from strong acids, strong oxidants, acid anhydrides and acid chlorides. Do NOT store or transport in containers made from iron, aluminium or copper and its alloys. Separated from food and feedstuffs.Store at room temperature

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

NIOSH considers amitrole to be a potential occupational carcinogen.

Decomposes on heating and on burning. This produces toxic fumes of nitrogen oxides. The substance is a weak base. Reacts violently with strong acids, strong oxidants, acid chlorides and acid anhydrides. This generates fire and explosion hazard.

No shelf life limitations

Aqueous, nonflammable, as amitrol-t; dry powder, non-flammable, as amizol.Dust explosion possible if in powder or granular form, mixed with air.AMITROLE is a triazole derivative. The triazoles are a group that contain several derivatives that are highly explosive materials. They are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazole ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. AMITROLE forms chelates with some metals. It is corrosive to iron, copper and aluminum. Forms salts with most acids and alkalis. This compound is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides (NTP, 1992).

no data available

Light (decomposes), strong oxidizers [Note: Corrosive to iron, aluminum & copper].

When strongly heated it emits highly toxic fumes of /nitrogen oxides/.

Acute toxicity

• Oral: LD50 Mouse oral 14.7 g/kg
• Inhalation: LC50 Mouse inhalation 439 mg/cu m/4 hr
• Dermal: LD50 Rat percutaneous >2500 mg/kg

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 /Pimephales promelas/ (Fathead minnow, weight 1.2 g) >100 mg/L/96 hr at 18 deg C. /static conditions without aeration
• Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; intoxication, immobilization) 30 ppm/48 hr; static /formulated product
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

Whatever the mechanism whereby triazole ring is opened, there appears to be little doubt that ring opening does occur rapidly in soils & resulting products (urea, cyanamid, & nitrogen) should be readily metabolized by soil microorganisms.

Carp exposed to 2 and 0.2 mg/L 2-amino-1,3,4-triazole over a 6 week incubation period had reported BCF values of <0.3 and <3, respectively(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).

Based on batch equilibrium experiments, 2-amino-1,3,4-triazole (dissolved in 1% sodium azide solutions) was determined to be mobile in silty clay, sandy loam, sand, and silt soils, with Freundlich Kf values of 0.152-0.922 ml/g(1). Freundlich Kf values were 0.714 (1/n = 0.7671) for the silty clay soil, 0.223 (1/n = 0.8549) for the sandy loam soil, 0.152 (1/n = 0.8722) for the sand soil, and 0.922 (1/n = 0.8590) for the silt soil; corresponding Koc values were 11.6, 29.7, 20.2, and 51.2, respectively(1). 2-Amino-1,3,4-triazole was mobile in these same soils when the soils were acidified to approximately pH 4.5; Freundlich Kf values ranged from 0.575-2.28. In another batch equilibrium study, 2-amino-1,3,4-triazole was determined to be mobile in Plainsfield sand (Kf = 0.685, 1/n = 0.7975), California sandy loam (Kf = 3.52, 1/n = 0.6487), Kewaunee silty clay loam (K = 1.57, 1/n = 0.8563), and Plano silt loam (Kf = 3.79, 1/n = 0.7739) soils(1). No discernible correlation between adsorption and either organic carbon content or CEC of the soils was observed(1). According to a classification scheme(2), these Koc values suggests that 2-amino-1,3,4-triazole is expected to have very high to high mobility in soil(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.Do NOT take working clothes home.