What is Benztropine Mesylate Used for? | Detailed Explanation

Before probing into the question of “what is benztropine mesylate used for”, the basic information about benztropine mesylate is introduced. Benzatropine mesylate is a class of anticholinergic agents that can restrain cholinergic receptors in the central nerve and help balance cholinergic transmission in the basal ganglia. 

Benztropine mesylate can inhibit the reuptake and preservation of dopamine in the central nervous system, thereby increasing dopaminergic activity. The specific mechanism by which anticholinergic drugs alleviate Parkinson's disease is unknown. Benztropine was approved for sale in the United States in 1954 and is widely used today.

What is benztropine mesylate used for?

This product has anticholine and antihistamine effects and has a mild local anesthetic effect. Clinical application of Parkinson's disease, including Parkinson's symptoms caused by reserpine, phenothiazine drugs. And the effect of it is better than that of benzoyl. 

In addition, the product has a weak inhibitory effect on smooth muscle and glands, and a strong anti-paralysis effect, which can improve muscle rigidity and tremor. It can also be used in drug-induced extrapyramidal reactions. Benztropine injections can also be used to treat acute dystonia.

The usage and dosage of benztropine mesylate

1. If we adopt the way of orally, the usual dosage for adults is one to two milligrams, twice a day. The dosage can be gradually increased according to needs and tolerance, generally not exceeding 6mg a day, divided into 3 times. Some patients only need to take 0.5 to 1mg before sleeping. Elderly patients who are more sensitive to this product should be reduced as appropriate. Children under 3 years of age do not use this product and 3 years of age or above should be in line with the doctor's discretion.

2.If the way of intramuscular or intravenous injection is taken, the common dosage for adults who have Parkinson's disease is 1 to 2mg each time, 1 to 2 times a day. If the patient has drug drug-induced extrapyramidal reaction, the dosage is 1 to 4mg once, 1 to 2 times a day.

The notices when using benztropine mesylate 

The topic of “what is benztropine mesylate used for” has been discussed, then it is necessary to introduce the notes when patients take it.

1.Use with caution in patients with heart, liver, and kidney disease.

2.Elderly patients may be more sensitive to this product and pay attention to adjusting the dose. The dosage of children under 3 years old is determined by the doctor according to the condition.

3.Patients with post-encephalitis palsy need a larger dose, not more than 30mg per day.

4.Use with phenothiazines or tricyclic antidepressants can cause intestinal paralysis.

5.In combination with selective 5-HT reuptake inhibitors, delirium may occasionally occur.

6. It is reported that we can use benztropine mesylate in combination with antipsychotics to treat hypothermia and fatal cardiogenic stroke.

Adverse reaction when using benztropine mesylate

Sometimes the patients who take benztropine mesylate are prone to show the symptoms of blurred vision, constipation, reduced sweating, difficulty or pain in urination, lethargy, dry mouth, nose or throat, and so on. It is likely to cause insomnia, vision, confusion, orientation disorders, speech disorders, and emotional instability, and seriously can cause insanity. Stop taking the medicine at this time. 

The contraindication when using benztropine mesylate

People who are allergic to this product, Tardive dyskinesia patients, and patients with untreated angle-closure glaucoma, of them are not allowed to take this medicine. Besides, it is not allowed for children under 3 years old.

Drug interaction

1.Combined with amantadine, it may enhance anticholinergic adverse reactions, and cause confusion and hallucination.

2. Combined with haloperidol and chlorazepine antipsychotics, adverse reactions can be increased due to the additive anticholinergic effect.

3. Combined with procainamine, it may lead to the addition of anti-vagal effects of the two.

4. Combined with Cisapride, it may antagonize the normal gastrointestinal peristalsis caused by Cisapride and make Cisapride ineffective.

Conclusion: 

This brings us to conclude our paper on the theme of "What is benztropine mesylate used for". Bentropine mesylate is mainly used to treat Parkinson's disease palsy tremor and drug-induced extrapyramidal reaction syndrome. There are many notices and contraindications when taking it, such as the person who has heart and liver disease, so we must take it according to the guidance of doctors.