Peptic ulcer disease (PUD) mainly refers to chronic ulcers that occur in the stomach and duodenal bulb. The formation of ulcers is related to the digestive effects of gastric acid and pepsin, hence the name. Ulcers refer to mucosal defects that exceed the muscularis mucosa, so they are different from erosions. Generally, they refer to gastric ulcers (GU) and duodenal ulcers (DU). Peptic ulcers in the elderly are more serious than those in the young, but the clinical symptoms are often atypical and prone to complications. Traditional treatments are less effective, and invasive treatments are limited by concomitant diseases. Although the diagnosis and treatment of peptic ulcers have made progress in recent years, the mortality rate of peptic ulcers in the elderly has tended to increase, so sufficient attention should be paid.