Bacterial keratitis was the most common infectious corneal disease in the 1960s. After the 1970s, viral keratitis, fungal keratitis, and acanthamoeba keratitis increased rapidly, but bacterial keratitis is still the infectious corneal disease with the highest incidence and blindness rate. The development trend of bacterial keratitis is the increasing number of opportunistic infections, mixed infections, and drug-resistant bacterial infections, which brings certain difficulties to the diagnosis and treatment of the disease. Ophthalmologists must be highly vigilant and pay attention to it. Bacterial keratitis often has risk factors, or related factors. Any factors that can destroy the integrity of tears, corneal epithelium, limbal blood vessels, and corneal endothelial cells can provide opportunities for bacterial infection. The most common related factors are trauma, corneal contact lens wear, ocular surface diseases, corneal surgery, local or systemic diseases, etc.