"Epidermolysis bullosa" (EB) was first proposed by Koebner in the late 19th century to describe a blistering skin disease that does not leave scars. It was later used to describe a group of multi-gene inherited skin diseases characterized by susceptibility of the skin and mucous membranes to mechanical damage and the formation of bullae. It is a typical group of diseases that invade the basement membrane zone of the skin and may also affect the internal organs. Clinically, the condition shows great variability. At the same time, genetic heterozygosity is also obvious, with autosomal dominant and recessive inheritance. Abnormal wound repair can lead to chronic damage and scabs, and metastatic cancer is also common. At present, significant progress has been made in the study of this disease, and its research methods are mainly through molecular cloning to encode some key protein base networks that maintain the integrity of the skin hierarchy. This disease also belongs to the category of "pemphigoid" in traditional Chinese medicine.