Neurofibromatosis (NF-1) is also a type of nevus hamartoma. Von Recklinghausen first reported the clinical and pathological changes of this disease in 1882, so it is also known as Recklinghausen disease and von Recklinghausen disease. It is a hereditary disease, which is autosomal dominant, with irregular penetrance, and the genetic characteristics are variability and high mutation rate. The incidence rate is about 1/3000 of newborns, and the age of onset can be at birth, late childhood or adulthood. This pathogen occurs in the growth and development disorders of neuroectodermal tissue cells, which is characterized by the proliferation of peripheral nerve fibers to form tumor-like nodules, invading the skin, internal organs, and nervous system, and accompanied by skin pigmentation spots. Clinically, it is characterized by abnormal skin pigment spots and multiple tumor-like proliferations of peripheral nerves in the trunk, limbs, and eyes, also known as multiple neurofibromatosis. This disease is mainly divided into 3 types. Type I is the peripheral type, which is the most common; Type II is the central type, with bilateral acoustic neuromas and a few skin lesions; Type III is the partial type, with lesions limited to a certain part of the body surface.