Beijing SL Pharmaceutical Co., Ltd.

Azithromycin is a 15-membered macrolide antibiotic. In vitro tests have shown that azithromycin has antibacterial effects on a variety of common clinical pathogens, including Gram-positive aerobic bacteria, Gram-negative aerobic bacteria, anaerobic bacteria, sexually transmitted disease microorganisms and other microorganisms. The mechanism of action is the same as that of erythromycin, mainly binding to the 50S subunit of the bacterial ribosome and inhibiting RNA-dependent protein synthesis.

Intraperitoneal injection of the drug into mice with cholestatic jaundice induced by 1-naphthyl isothiocyanate can reduce serum aspartate aminotransferase, alanine aminotransferase and serum conjugated bilirubin levels, and alleviate liver cell damage in the model animals.

Azithromycin is a 15-membered macrolide antibiotic. In vitro tests have shown that azithromycin has antibacterial effects on a variety of common pathogens in clinical practice, including Gram-positive aerobic bacteria, Gram-negative aerobic bacteria, anaerobic bacteria, sexually transmitted disease microorganisms and other microorganisms. Its mechanism of action is the same as that of erythromycin, mainly binding to the 50S subunit of the bacterial ribosome and inhibiting RNA-dependent protein synthesis.

This product is a chemical semi-synthetic clindamycin derivative with no antibacterial activity in vitro. It is hydrolyzed into clindamycin after entering the body and shows pharmacological activity. The antibacterial spectrum, antibacterial activity and therapeutic effect are the same as those of clindamycin, and its fat solubility and permeability are better than those of clindamycin. It can be administered by intramuscular injection and intravenous drip. The antibacterial effect is 4 to 8 times stronger than that of lincomycin, with good absorption and high bone concentration, and good efficacy against anaerobic infections. It has strong antibacterial activity mainly against Gram-positive cocci (such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus, etc.) and anaerobic bacteria (such as Clostridium, Bacteroides, etc.).

It can inhibit the pathological excessive secretion of growth hormone, thyroid-stimulating hormone, gastrointestinal and pancreatic endocrine hormones; it can selectively reduce the blood flow and pressure of the portal vein and its collateral circulation, and reduce the pressure of varicose veins in the esophagus and gastric fundus; it can inhibit gallbladder emptying and have a therapeutic effect on pancreatic lesions; it can inhibit the secretion of gastric acid and gastrin, and improve the blood supply to the gastric mucosa; it can inhibit gastrointestinal motility.