Jilin Sihuan Pharmaceutical Company Limited

It can increase the cAMP content in platelets by reversibly binding to adenosine carrier protein on the platelet cell membrane, thereby inhibiting platelet aggregation and preventing thrombosis. It can also counteract vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability.

It can penetrate the blood-brain barrier, adjust and improve the protein synthesis and nucleic acid metabolism of neurons, promote the formation of synapses, and induce the differentiation of neurons; it can also affect the respiratory chain, improve the energy metabolism in the brain, increase the utilization of glucose by brain tissue, improve the hypoxic state of brain cells, and have a protective effect on hypoxic brain tissue; it can provide neurotransmitters, peptide hormones, and coenzyme precursors, activate and improve the activity of neurotransmitters and enzymes in the brain, and protect nerve cells from damage caused by various ischemia and neurotoxins.

Pharmacological action: Troxerutin can increase the cAMP content in platelets by reversibly binding to adenosine carrier protein on the platelet cell membrane, thereby inhibiting platelet aggregation and preventing thrombosis. At the same time, it can counteract vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability. The large amount of active peptides, various amino acids and nucleic acid metabolites contained in this product can pass through the blood-brain barrier, adjust and improve the protein synthesis and nucleic acid metabolism of neurons, promote the formation of synapses, and induce the differentiation of neurons; and affect its respiratory chain, improve energy metabolism in the brain, increase the utilization of glucose by brain tissue, improve the state of brain cell deficiency, and have a protective effect on hypoxic brain tissue; it can provide neurotransmitters, peptide hormones and coenzyme precursors, activate and improve the activity of neurotransmitters and enzymes in the brain, and protect nerve cells from damage by various ischemia and neurotoxins. Toxicological study: Acute toxicity test shows that the maximum tolerance dose of intravenous injection equivalent to crude drug is 3.2 g/kg. The D50 of the test substance for intravenous injection of mice is greater than 3.2 g/kg, and the maximum tolerance multiple of mice is 400 times, which is actually non-toxic. Safety experiment shows that this product has no obvious irritation to the quadriceps of rabbits; no obvious irritation to the venous blood vessels of rabbits; allergy test shows that this product has no sensitization effect on guinea pigs, and in vitro hemolysis test shows that this product has no hemolysis or agglutination effect on rabbit red blood cells within 4 hours.

It can penetrate the blood-brain barrier, adjust and improve the protein synthesis and nucleic acid metabolism of neurons, promote the formation of synapses, and induce the differentiation of neurons; it can also affect the respiratory chain, improve the energy metabolism in the brain, increase the utilization of glucose by brain tissue, improve the hypoxic state of brain cells, and have a protective effect on hypoxic brain tissue; it can provide neurotransmitters, peptide hormones, and coenzyme precursors, activate and improve the activity of neurotransmitters and enzymes in the brain, and protect nerve cells from damage caused by various ischemia and neurotoxins.

It can reversibly bind to the adenosine carrier protein on the platelet cell membrane, increase the cAMP content in the platelets, thereby inhibiting platelet aggregation and preventing thrombosis. At the same time, it can counteract the vascular damage caused by serotonin and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability.

It can penetrate the blood-brain barrier, adjust and improve the protein synthesis and nucleic acid metabolism of neurons, promote the formation of synapses, and induce the differentiation of neurons; it can also affect the respiratory chain, improve the energy metabolism in the brain, increase the brain tissue's utilization of glucose, improve the hypoxic state of brain cells, and have a protective effect on hypoxic brain tissue; it can provide neurotransmitters, peptide hormones, and coenzyme precursors, activate and improve the activity of neurotransmitters and enzymes in the brain, and protect nerve cells from damage caused by various ischemia and neurotoxins.

It can penetrate the blood-brain barrier, adjust and improve the protein synthesis and nucleic acid metabolism of neurons, promote the formation of synapses, and induce the differentiation of neurons; it can also affect the respiratory chain, improve the energy metabolism in the brain, increase the brain tissue's utilization of glucose, improve the hypoxic state of brain cells, and have a protective effect on hypoxic brain tissue; it can provide neurotransmitters, peptide hormones, and coenzyme precursors, activate and improve the activity of neurotransmitters and enzymes in the brain, and protect nerve cells from damage caused by various ischemia and neurotoxins.

The specific pharmacological effects are not clearly mentioned.

It has an inhibitory effect on a variety of Gram-positive and Gram-negative bacteria in vitro, and has a stronger inhibitory effect on hemolytic Streptococcus, Staphylococcus aureus, Vibrio cholerae, Neisseria meningitidis, Shigella, Salmonella typhi, Corynebacterium diphtheriae, etc. It also has a certain inhibitory effect on amoeba.

It mainly interferes with bacterial folate metabolism, selectively inhibits dihydrofolate reductase, and prevents nucleic acid synthesis.

It is a choleretic and anti-inflammatory drug that decomposes into nicotinamide and formaldehyde after entering the body. The former has a liver-protecting effect, while the latter has an antibacterial effect, and can inhibit infections caused by diplococci, staphylococci, enterococci and Escherichia coli in the bile duct and intestines.

This product is a quinolone antibacterial drug that acts on bacterial DNA gyrase to interfere with bacterial DNA synthesis, thereby causing bacterial death. It has antibacterial effects on Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Serratia, Salmonella typhi, Shigella, Pseudomonas aeruginosa, etc.