Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.

It combines with pyrophosphate in the body to form a coenzyme, participates in the oxidative decarboxylation reaction of pyruvate and α-ketoglutarate in sugar metabolism, and is necessary for sugar metabolism. When it is deficient, oxidation is blocked to form pyruvate and lactic acid accumulation, which affects the body's energy supply. Its symptoms are mainly manifested in the nervous and cardiovascular systems, with multiple peripheral neuritis affecting both sensory nerves and motor nerves, manifested as paresthesia, neuralgia, limb weakness, muscle soreness and atrophy. In terms of cardiovascular, due to the increase of acetone and lactic acid in the blood, the small arteries are dilated, the diastolic pressure is reduced, and the myocardial metabolism is disturbed, so it is easy to have symptoms of heart failure such as palpitations, shortness of breath, chest tightness, cardiac hypertrophy, liver and lung congestion and peripheral edema. In terms of the digestive tract, it is manifested as weakness and weight loss caused by decreased appetite.

It combines with pyrophosphate in the body to form a coenzyme, participates in the oxidative decarboxylation reaction of pyruvate and α-ketoglutaric acid in sugar metabolism, and is necessary for sugar metabolism. When it is deficient, oxidation is blocked to form pyruvate and lactic acid accumulation, which affects the body's energy supply. Its symptoms are mainly manifested in the nervous and cardiovascular systems, with multiple peripheral neuritis affecting both sensory nerves and motor nerves, manifested as paresthesia, neuralgia, limb weakness, muscle soreness and atrophy. In terms of cardiovascular, due to the increase of acetone and lactic acid in the blood, the small arteries are dilated, the diastolic pressure is reduced, and the myocardial metabolism is disturbed, so it is easy to have symptoms of heart failure such as palpitations, shortness of breath, chest tightness, cardiac hypertrophy, liver and lung congestion and peripheral edema. In terms of the digestive tract, it is manifested as weakness and weight loss caused by decreased appetite.

It can obviously inhibit the synthesis of tumor cell DNA; it has anti-tumor effect; it can easily penetrate the blood-brain barrier and has good therapeutic effect on brain tumors and brain metastases; when used in combination with chemotherapy drugs, it can significantly enhance the growth inhibition rate of cancer cells; it is a cell cycle non-specific anticancer drug, which has killing and inhibitory effects on cancer cells at all stages.

It has a reversal effect on the drug resistance of human gastric cancer cells resistant to chemotherapy drugs; it has a certain inhibitory effect on gastric cancer cell lines; it directly enters cancer cells and causes them to degenerate and necrotize by affecting the plasma membrane system and mitochondria; it has a good therapeutic effect on lung cancer, esophageal cancer, primary liver cancer, colorectal cancer, pancreatic cancer, lung cancer, cervical cancer, bladder cancer, prostate cancer and other solid tumors, metastatic cancer (such as brain metastasis of lung cancer, metastatic liver cancer, etc.) and cancerous pleural effusions and ascites.

Inhibits cyclooxygenase activity, thereby blocking the conversion of arachidonic acid to prostaglandins. It also promotes the binding of arachidonic acid to triglycerides, reduces the concentration of free arachidonic acid in cells, and indirectly inhibits the synthesis of leukotrienes. Its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin.

It has antipyretic, analgesic, sedative and anti-inflammatory effects

It can counteract the allergic reaction of histamine by antagonizing H1 receptors, does not affect histamine metabolism, does not prevent the release of histamine in the body, and has M cholinergic receptor blocking and central inhibition effects