Chongqing Lummy Pharmaceutical Co., Ltd.

This product is a potassium sodium salt of dehydrated andrographolide succinate half ester made from the plant Andrographolide extract through esterification, dehydration and salt formation. It is the same substance as the active metabolite of Andrographolide in the body. It has antipyretic, anti-inflammatory and sedative effects, can promote the disappearance of fever, counteract the increased permeability of capillary walls, enhance the sedative effect of sodium pentobarbital, promote adrenal cortex function, and has an in vitro inactivation effect on a variety of viruses.

This product has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins, can promote the disappearance of fever, the effect is rapid and can last for more than 4 hours; it can counteract the increased permeability of capillary walls caused by xylene or histamine; it can shorten the sleep latency of mice caused by sodium pentobarbital, prolong their sleep time, and can also enhance the subthreshold effect of sodium pentobarbital to induce sleep in mice, indicating that this product has a significant sedative effect; it can significantly promote the adrenal cortex function of rats and increase the body's emergency response to pathogen infection; it has a certain inactivation effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type III, type IV, and enterosyncytial virus (Rsv) in vitro.

Quinolone antibiotics exert broad-spectrum antibacterial effects by inhibiting bacterial DNA helicase, and have antibacterial activity against Enterobacter bacteria (such as Escherichia coli, Klebsiella, Proteus, Shigella, Salmonella typhi, etc.), influenza bacilli, Neisseria, Staphylococcus aureus and Pseudomonas aeruginosa. They have only mild effects on pneumococci, various groups of streptococci and enterococci.

Quinolone antibacterial drugs inhibit bacterial DNA helicase and have a broad-spectrum antibacterial effect. They have strong antibacterial activity against Enterobacter bacteria such as Escherichia coli, Klebsiella, Proteus, Shigella, Salmonella typhi, etc., as well as influenza bacillus and Neisseria. They also have certain antibacterial effects on Staphylococcus aureus and Pseudomonas aeruginosa. They have only mild effects on pneumococci, various groups of streptococci and enterococci.

It has high antibacterial activity against most aerobic Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Oxytobacter, aerogenes, Cloacae, Proteus, Serratia, Citrobacter, Shigella and other Enterobacteriaceae, as well as influenza bacilli, gonococci, meningococci, etc. It also has good antibacterial effect against Pseudomonas aeruginosa, but has poor antibacterial effect against some Pseudomonas and Acinetobacter species other than Pseudomonas aeruginosa, and has no antibacterial activity against aerobic Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as anaerobic bacteria. Aztreonam exerts its bactericidal effect by binding to penicillin-binding protein 3 (PBP3) on the cell membrane of sensitive aerobic Gram-negative bacteria and inhibiting the synthesis of bacterial cell walls.