Nicotinic acid is converted into nicotinamide in the body, and then combined with riboadenin to form nicotinamide adenine dinucleotide (coenzyme I) and nicotinamide adenine dinucleotide phosphate (coenzyme II), which are necessary for lipid amino acid, protein, purine metabolism, tissue respiration oxidation and glycogenolysis. Nicotinic acid can reduce the utilization of coenzyme A; by inhibiting the synthesis of very low density lipoprotein (VLDL), it affects the transport of cholesterol in the blood. Large doses can reduce serum cholesterol and triglyceride concentrations. Nicotinic acid has a peripheral vasodilation effect.

Antipyretic and analgesic effects

No specific pharmacological effects mentioned

Anti-allergic effect

No specific pharmacological effects mentioned

Broad-spectrum antiviral drug. It has the effect of inhibiting the growth of multiple viruses such as respiratory syncytial virus, influenza virus, hepatitis A virus, adenovirus, etc. in vitro, and its mechanism is not fully understood. After entering the virus-infected cells, the drug is rapidly phosphorylated, and its product acts as a competitive inhibitor of viral synthase, inhibiting inosine monophosphate dehydrogenase, influenza virus RNA polymerase and mRNA guanosine transferase, thereby causing a decrease in intracellular guanosine triphosphate, impairing viral RNA and protein synthesis, and inhibiting viral replication and transmission. It may also have an immune effect and neutralizing antibody effect on respiratory syncytial virus.

It inhibits the synthesis and release of prostaglandins in the hypothalamus, restores the normal responsiveness of the sensory neurons in the temperature regulation center, and has an antipyretic effect; it has an analgesic effect by inhibiting the synthesis of prostaglandins, etc.; it inhibits the synthesis and release of prostaglandins in the local tissue of inflammation, stabilizes lysosomal enzymes, and affects the phagocytic function of phagocytes, thus playing an anti-inflammatory role

By inhibiting the synthesis and release of prostaglandins (PGE1) in the hypothalamic temperature regulation center, peripheral vasodilation occurs, causing sweating to achieve an antipyretic effect; inhibiting the effects of PGE1, bradykinin and histamine, etc., raising the pain threshold and producing analgesic effects

Excites the cerebral cortex, increases sensitivity to the outside world, and constricts cerebral blood vessels, enhancing the effect of the first two drugs in relieving headaches

It has a strong histamine H1 receptor blocking effect, can alleviate other respiratory symptoms caused by allergies, and also has a mild inhibitory effect on the central nervous system