Ribavirin
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Ribavirin
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CAS No:
36791-04-5
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Formula:
C8H12N4O5
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Chemical Name:
Ribavirin
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Synonyms:
1H-1,2,4-Triazole-3-carboxamide,1-β-D-ribofuranosyl-;1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide;Virazole;1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide;ICN 1229;Ribavirin;Viramid;1-β-D-Ribofuranosyl-1,2,4-triazol-3-carboxyamide;NSC 163039;Vilona;Ribamide;Ribamidil;Tribavirin;Rebetol;Ribavarin;Ravanex;Copegus;Ribasphere;Virizadole;MegaRibavirin;EBP 954;Meduna;Virin;1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide;Cotronak;66510-90-5;437710-49-1
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CAS No:
Description
Ribavirin is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.
1-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,2,4-triazole-3-carboxamide is a nucleobase-containing molecular entity.|A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Characteristics
143.72000
-1.8
Ribavirin is a white powder. Exists in two polymorphic forms. (NTP, 1992)
2.08 g/cm3
166-168 °C
639.8ºC at 760 mmHg
340.7ºC
1.823
H2O: soluble
2-8ºC
5.1X10-13 mm Hg at 25 deg C (est)
LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)
Specific optical rotation: -36.5 deg at 25 °C/D
Odorless
Tasteless
Safety Information
II
9
UN 3152 9/PG 2
3
R61
53-22-45-37/39-26
XZ4250000
Xi
Ribavirin solutions contain no preservatives and are stable for 24 hr when stored under sterile conditions at a room temperature of 20-30 deg C. Following addition of the reconstituted solution to the reservoir of the SPAG-2 and further dilution with sterile water for injection or inhalation (additive free), the ribavirin solution for nebulization should be discarded within 24 hr.
P201-P280-P308 + P313
H360
Drug Information
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Antimetabolites.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)
ICN 1229
Ribavirin Use and Manufacturing
Used as an antiviral agent Ribavirin has a wide range of uses in medicine. It is clinically effective against hepatitis A, influenza, various herpes, as well as infections of respiratory syncytial virus, human immunodeficiency virus, epidemic hemorrhagic fever virus, skin diseases, etc. Efficacy. Ribavirin is the only effective drug for the treatment of respiratory syncytial virus and the first choice for the treatment of epidemic hemorrhagic fever. In recent years, its application to hepatitis B and hepatitis C has also shown good results. In India, the drug is approved for the treatment of acute hepatitis, respiratory tract infection and herpes simplex infection.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:244.20
XLogP3:-1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:244.08076950
Monoisotopic Mass:244.08076950
Topological Polar Surface Area:144
Heavy Atom Count:17
Complexity:304
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Broad-spectrum antiviral drug. It has the effect of inhibiting the growth of multiple viruses such as respiratory syncytial virus, influenza virus, hepatitis A virus, adenovirus, etc. in vitro. After entering the virus-infected cells, the drug is rapidly phosphorylated, and its product acts as a competitive inhibitor of viral synthase, inhibiting inosine monophosphate dehydrogenase, influenza virus RNA polymerase and mRNA guanosine transferase, thereby causing a decrease in intracellular guanosine triphosphate, impairing viral RNA and protein synthesis, and inhibiting viral replication and transmission. It may also have an immune effect and neutralizing antibody effect on respiratory syncytial virus.
Registered Holders
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APITORIA PHARMA PRIVATE LTD
Active
United States
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SIEGFRIED EVIONNAZ SA
Active
France
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Zhejiang Cheng Yi Pharmaceutical Co., Ltd.
Active
China
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